Study Report
Basic Info
| Reference |
Georgi, A., 2006 PMID: 16969270
|
| Citation |
Georgi, A., R. A. Jamra, et al. (2006). "No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample." Psychiatr Genet 16(5): 183-184.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
306 BD patients and 319 controls |
| SNP/Region/Marker Size |
5 variants |
| Predominant Ethnicity |
Caucasian |
| Population |
German |
| Gender |
53% women and 47% men patients; 58% women and 42% men controls |
| Age Group |
adults
:
mean age 42.4 (SD=13.3) years of cases, mean age 49.2 (SD=15.5) years of controls
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
Lifetime best estimate diagnoses were based on the Diagnostic and Statistical Manual of Mental Disorder-IV. |
| Result Summary |
Allele and haplotype frequencies did not differ between cases and controls. For the two previously associated markers, the allele frequencies were as follows: rs11146020 (cases 93.9% G, 6.1% C; controls 93.3% G, 6.7% C) and rs10747050 (cases 95.8% A, 4.2% G; controls 94.6% A, 5.4% G). Given their recent finding that the association between G72/G30 and BD was mainly due to a lifetime history of persecutory delusions and that G72/G30 is supposed to play a pivotal role in the activation of the NR1 subunit, they hypothesized that restricting case definition to those 107 individuals with a history of persecutory delusions might clarify the relationship between BD and GRIN1. However, this stratified analysis did not yield any significant association either. Their results do not support an association of the GRIN1 gene with BD in the German population. |
SNPs reported by this study for BD (count: 4)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs6293 |
GRIN1
|
|
|
data not shown
|
Allele and haplotype frequencies did not differ between case......
Allele and haplotype frequencies did not differ between cases and controls.
More...
|
Negative
|
| rs4880213 |
GRIN1
|
|
|
data not shown
|
Allele and haplotype frequencies did not differ between case......
Allele and haplotype frequencies did not differ between cases and controls.
More...
|
Negative
|
| rs11146020 |
GRIN1
|
G/C |
|
data not shown
|
Allele and haplotype frequencies did not differ between case......
Allele and haplotype frequencies did not differ between cases and controls.
More...
|
Negative
|
| rs10747050 |
GRIN1
|
A/G |
|
data not shown
|
Allele and haplotype frequencies did not differ between case......
Allele and haplotype frequencies did not differ between cases and controls.
More...
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| GRIN1 |
Our results do not support an association of the GRIN1 gene with BD in the German population.
Our results do not support an association of the GRIN1 gene with BD in the German population.
|
Negative
|
