BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Kerner, B.,2009 PMID: 18484081
Citation	Kerner, B., A. J. Jasinska, et al. (2009). Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 150B(1): 24-32.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	60 families (330 individuals):23 families (131 individuals) in Wave1;37 families (46 nuclear families,199 individuals) in Wave2,3,4
SNP/Region/Marker Size	1,149 SNPs
Predominant Ethnicity
Population	NIMH collections

Detail Info

SNPs reported by this study for BD (count: 16)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4958751		T/C		FBAT: Waves 1-4: Z-score=2.9, P-value = 0.004	Significant association was observed in Wave 1-4. Significant association was observed in Wave 1-4.	Positive
rs490922	GRIA1	C/T		FBAT: Wave 1: Z-score=3.3, P-value = 0.001; Waves 2-4: Z-score=0, P-value = 1; Waves 1-4: Z-score=2.7, P-value = 0.008	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs524905	GRIA1	C/T		FBAT: Wave 1: Z-score=2.7, P-value = 0.008; Waves 2-4: Z-score=0.9, P-value = 0.4; Waves 1-4: Z-score=2.6, P-value = 0.01	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs524610	GRIA1	A/G		FBAT: Wave 1: Z-score=3.3, P-value = 0.001; Waves 1-4: Z-score=2.8, P-value = 0.005	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs452223	ITK	G/A		FBAT: Wave 1: Z-score=2.4, P-value = 0.01; Waves 1-4: Z-score=3.1, P-value = 0.002	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs4385264	GRIA1	A/G		FBAT: Wave 1: Z-score=0.1, P-value = 0.9; Waves 2-4: Z-score=3.2, P-value = 0.002; Waves 1-4: Z-score=2.2, P-value = 0.03	Significant association was observed in Wave 2-4 and Wave 1-...... Significant association was observed in Wave 2-4 and Wave 1-4. More...	Positive
rs472792	GRIA1	G/T		FBAT: Wave 1: Z-score=2.6, P-value = 0.009; Waves 2-4: Z-score=1.1, P-value = 0.3; Waves 1-4: Z-score=2.8, P-value = 0.006	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs4704916		A/G		FBAT: Wave 1: Z-score=2.3, P-value = 0.02; Waves 1-4: Z-score=2.9, P-value = 0.003	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs9284996		C/T		FBAT: Wave 1: Z-score=2.6, P-value = 0.009; Waves 2-4: Z-score=1.1, P-value = 0.3; Waves 1-4: Z-score=2.8, P-value = 0.006	Significant association was observed in Wave 1-4. Significant association was observed in Wave 1-4.	Positive
rs6882516	LSM11	A/C		FBAT: Wave 1: Z-score=2.1, P-value = 0.04; Waves 1-4: Z-score=2.6, P-value = 0.009	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs6874808	EBF1	T/C		FBAT: Waves 1-4: Z-score=2.7, P-value = 0.008	Significant association was observed in Wave 1-4. Significant association was observed in Wave 1-4.	Positive
rs885466		A/G		FBAT: Wave 1: Z-score=2.9, P-value = 0.004; Waves 1-4: Z-score=2.9, P-value = 0.004	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs7734683		C/T		FBAT: Waves 1-4: Z-score=2.6, P-value = 0.01	Significant association was observed in Wave 1-4. Significant association was observed in Wave 1-4.	Positive
rs1295213		G/T		FBAT: Waves 2-4: Z-score=2.1, P-value = 0.04; Waves 1-4: Z-score=2.9, P-value = 0.004	Significant association was observed in Wave 2-4 and Wave 1-...... Significant association was observed in Wave 2-4 and Wave 1-4. More...	Positive
rs1864205	GRIA1	A/G		FBAT: Wave 1: Z-score=3.2, P-value = 0.002; Waves 2-4: Z-score=0.4, P-value = 0.7; Waves 1-4: Z-score=2.3, P-value = 0.02	Significant association was observed in Wave 1 and Wave 1-4. Significant association was observed in Wave 1 and Wave 1-4.	Positive
rs1914212		A/C		FBAT: Waves 1-4: Z-score=2.8, P-value = 0.006	Significant association was observed in Wave 2-4 and Wave 1-...... Significant association was observed in Wave 2-4 and Wave 1-4. More...	Positive

Genes reported by this study for BD (count: 4)

Gene	Statistical Values/Author Comments	Result Category
EBF1	Only a small number of families had been informative for those SNPs in the individual data sets, the...... Only a small number of families had been informative for those SNPs in the individual data sets, therefore the analysis of all families combined increased the evidence for those loci. More...	Positive
LSM11	Only a small number of families had been informative for those SNPs in the individual data sets, the...... Only a small number of families had been informative for those SNPs in the individual data sets, therefore the analysis of all families combined increased the evidence for those loci. More...	Positive
ITK	Only a small number of families had been informative for those SNPs in the individual data sets, the...... Only a small number of families had been informative for those SNPs in the individual data sets, therefore the analysis of all families combined increased the evidence for those loci. More...	Positive
GRIA1	Our findings suggest that variations in GRIA1 may contribute to the pathophysiology of BP with psych...... Our findings suggest that variations in GRIA1 may contribute to the pathophysiology of BP with psychotic features in some families More...	Positive