SNP Report

Basic Info

Name	rs2306987 dbSNP Ensembl
Location	chr4:186595501 - 186595501(1)
Variant Alleles	T/A
Ancestral Allele	T
Minor Allele	A
Minor Allele Frequence	0.283746
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000503253, ENST00000507662, ENST00000512347); intron_variant(ENST00000441802, ENST00000500085, ENST00000507105, ENST00000509537, ENST00000509927, ENST00000512772, ENST00000614102); NMD_transcript_variant(ENST00000509537); non_coding_transcript_variant(ENST00000500085)
No. of Studies	2 (Positive: 2; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Abou Jamra, R, 2008 (a)	A/T		allelic P-value = 0.02326; OR=1.50 allelic P-value = 0.02326; OR=1.50	showed association with bipolar affective disorder showed association with bipolar affective disorder	Positive
Blair, I. P., 2006			Allelic P-value = 0.02, genotypic P-value = 0.005 in Aust ca...... Allelic P-value = 0.02, genotypic P-value = 0.005 in Aust case-control; Allelic P-value = 0.463, genotypic P-value = 0.439 in UK case-control; Allelic P-value = 0.084 in UK trios; Allelic P-value > 0.5 in Bulgarian trios for overall; Allelic P-value = 0.01, genotypic P-value = 0.004 in Aust case-control; Allelic P-value = 0.365, genotypic P-value = 0.592 in UK case-control; Allelic P-value = 0.06 in UK trios; Allelic P-value = 0.128 in Bulgarian trios with positive family history; Allelic P-value = 0.384, genotypic P-value = 0.228 in Aust case-control; Allelic P-value = 0.05, genotypic P-value = 0.022 in UK case-control with negative family history; Allelic P-value = 0.178, genotypic P-value = 0.261 in Aust case-control; Allelic P-value = 0.329, genotypic P-value = 0.484 in UK case-control; Allelic P-value = 0.003 in UK trios; Allelic P-value = 0.024 in Bulgarian trios with lifetime psychotic episode; Allelic P-value = 0.013, genotypic P-value = 0.005 in Aust case-control; Allelic P-value = 0.947, genotypic P-value = 0.298 in UK case-control; Allelic P-value > 0.5 in UK trios; Allelic P-value = 0.058 in Bulgarian trios with no psychotic episode; pooled P-value = 0.083, OR=1.19 More...	The SNP provided statistically significant evidence for asso...... The SNP provided statistically significant evidence for association in the Australian case-control cohort. In the pooled data analysis, SNP rs2306987 showed weak evidence for association (P=0.06) with a summary OR of 1.27 (95% CI: 0.99-1.64).Statistically significant evidence for association was observed in the UK case-control cohort for those cases without a family history of mental illness. Neither the UK trios nor the Bulgarian trios showed evidence for association among family history or non-family history subsets. However, both trio cohorts did show statistically significant evidence for association among those bipolar cases who had exhibited psychosis More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CD36	CD36 molecule (thrombospondin receptor)	7q11.2	3(2/1/0)
FAT1	FAT atypical cadherin 1	4q35.2	Mapped by Literature SNP

SNPs in LD with rs2306987 (count: 0) View in gBrowse (chr4:186595501..186595501 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)