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Reference | Smith, E. N.,2011 PMID: 21738484 |
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Citation | Smith, E. N., D. L. Koller, et al. (2011). "Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes." PLoS Genet 7(6): e1002134. |
Disease Type | Bipolar Disorder |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | 1,190 BD cases and 401 controls |
SNP/Region/Marker Size | 728,187 SNPs |
Predominant Ethnicity | |
Population | TGEN and GAIN collection |
Replication Size | 2,191 BD cases and 1,434 controls |
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Statistical Method | Association analysis was performed on the genotype data in PLINK using logistic regression, adjusting for study in the GAIN+TGEN sample, and using the -dosage command with the predictor being the maximum likelihood estimate of the number of alleles at the locus (format = 1). |
Result Summary | We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5x10(-7)). These results indicate that there is likely common genetic variation associated with BD near exons (+/-10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs7755802 | MUC22 DPCR1 | A/G | Genome-Wide Association: OR=0.78, P-value = 1.4E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs7747960 | SYNE1 | A/C | Genome-Wide Association: OR=1.29, P-value = 0.0007 | No significant association was observed. No significant association was observed. | Negative | |
rs9554603 | LINC00449 TM9SF2 | G/T | Genome-Wide Association: OR=0.74, P-value = 9.0E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs17498753 | CAMKMT | G/A | Genome-Wide Association: OR=0.71, P-value = 1.0E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs1927252 | NEK7 | A/C | Genome-Wide Association: OR=1.35, P-value = 3.6E-07 | Suggestive association was found. Suggestive association was found. | Trend | |
rs2367911 | CACNA2D1 | T/C | Genome-Wide Association: OR=2, P-value = 5.9E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs2989476 | NFIA | C/G | Genome-Wide Association: OR=1.12, P-value = 0.0299 | No significant association was observed. No significant association was observed. | Negative | |
rs4770394 | SGCG | G/A | Genome-Wide Association: OR=0.74, P-value = 0.043 | No significant association was observed. No significant association was observed. | Negative | |
rs6475738 | ELAVL2 | C/G | Genome-Wide Association: OR=0.8, P-value = 9.2E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs7560357 | MGAT4A | G/T | Genome-Wide Association: OR=1.43, P-value = 4.5E-07 | Suggestive association was found. Suggestive association was found. | Trend | |
rs7703177 | FST | C/T | Genome-Wide Association: OR=1.29, P-value = 5.1E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs1038094 | CD276 | A/G | Genome-Wide Association: OR=0.79, P-value = 0.003 | No significant association was observed. No significant association was observed. | Negative | |
rs12618769 | MGAT4A UNC50 | T/C | Genome-Wide Association: OR=1.43, P-value = 8.32 x 10-7 | Suggestive association was found. Suggestive association was found. | Trend | |
rs1585913 | CXCL12 | A/G | Genome-Wide Association: OR=0.79, P-value = 2.5E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
rs17197037 | HNRNPC | A/G | Genome-Wide Association: OR=1.16, P-value = 0.0044 | No significant association was observed. No significant association was observed. | Negative |
Gene | Statistical Values/Author Comments | Result Category |
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CAMKMT | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
FST | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
CXCL12 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
TM9SF2 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
ELAVL2 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
CD276 | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
CACNA2D1 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
SGCG | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
SYNE1 | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
HNRNPC | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
NFIA | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
NEK7 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
MGAT4A | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
DPCR1 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016