Search SNP
Search Gene
Search CNV
Search Haplotype
Search Other Variant
Search Region
Search Pathway
Search Study
Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Smith, E. N.,2011 PMID: 21738484 |
|---|---|
| Citation | Smith, E. N., D. L. Koller, et al. (2011). "Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes." PLoS Genet 7(6): e1002134. |
| Disease Type | Bipolar Disorder |
| Study Design | case-control |
| Study Type | Candidate-gene association study |
| Sample Size | 1,190 BD cases and 401 controls |
| SNP/Region/Marker Size | 728,187 SNPs |
| Predominant Ethnicity | |
| Population | TGEN and GAIN collection |
Detail Info
| Replication Size | 2,191 BD cases and 1,434 controls |
|---|---|
| Statistical Method | Association analysis was performed on the genotype data in PLINK using logistic regression, adjusting for study in the GAIN+TGEN sample, and using the -dosage command with the predictor being the maximum likelihood estimate of the number of alleles at the locus (format = 1). |
| Result Summary | We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5x10(-7)). These results indicate that there is likely common genetic variation associated with BD near exons (+/-10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs7755802 | MUC22 DPCR1 | A/G | Genome-Wide Association: OR=0.78, P-value = 1.4E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs7747960 | SYNE1 | A/C | Genome-Wide Association: OR=1.29, P-value = 0.0007 | No significant association was observed. No significant association was observed. | Negative | |
| rs9554603 | LINC00449 TM9SF2 | G/T | Genome-Wide Association: OR=0.74, P-value = 9.0E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs17498753 | CAMKMT | G/A | Genome-Wide Association: OR=0.71, P-value = 1.0E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs1927252 | NEK7 | A/C | Genome-Wide Association: OR=1.35, P-value = 3.6E-07 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs2367911 | CACNA2D1 | T/C | Genome-Wide Association: OR=2, P-value = 5.9E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs2989476 | NFIA | C/G | Genome-Wide Association: OR=1.12, P-value = 0.0299 | No significant association was observed. No significant association was observed. | Negative | |
| rs4770394 | SGCG | G/A | Genome-Wide Association: OR=0.74, P-value = 0.043 | No significant association was observed. No significant association was observed. | Negative | |
| rs6475738 | ELAVL2 | C/G | Genome-Wide Association: OR=0.8, P-value = 9.2E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs7560357 | MGAT4A | G/T | Genome-Wide Association: OR=1.43, P-value = 4.5E-07 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs7703177 | FST | C/T | Genome-Wide Association: OR=1.29, P-value = 5.1E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs1038094 | CD276 | A/G | Genome-Wide Association: OR=0.79, P-value = 0.003 | No significant association was observed. No significant association was observed. | Negative | |
| rs12618769 | MGAT4A UNC50 | T/C | Genome-Wide Association: OR=1.43, P-value = 8.32 x 10-7 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs1585913 | CXCL12 | A/G | Genome-Wide Association: OR=0.79, P-value = 2.5E-06 | Suggestive association was found. Suggestive association was found. | Trend | |
| rs17197037 | HNRNPC | A/G | Genome-Wide Association: OR=1.16, P-value = 0.0044 | No significant association was observed. No significant association was observed. | Negative |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| CAMKMT | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| FST | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| CXCL12 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| TM9SF2 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| ELAVL2 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| CD276 | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
| CACNA2D1 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| SGCG | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
| SYNE1 | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
| HNRNPC | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
| NFIA | No significant association of this gene was observed in BD. No significant association of this gene was observed in BD. | Negative |
| NEK7 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| MGAT4A | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
| DPCR1 | Suggestive association of this gene was found. Suggestive association of this gene was found. | Trend |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
To view this website normally, please make sure to allow Flash to run from the local filesystem in the security settings panel.
Last update: March 31, 2016