Region Report

Basic Info

Region Name	12q24
Chromosome Position	chr12:108600000-133275309
No. of Studies (Positive/Negative/Trend)	4(1/1/2)

Region related studies (count: 4)

Reference	Markers	Statistical Values	Author Comments	Result Category
McInnis, M. G.,2003(b)	D12S69d	Linkage analysis: Model BPUP, NPL = 2.08, P-value = 0.02, LO...... Linkage analysis: Model BPUP, NPL = 2.08, P-value = 0.02, LOD(ASM) = 1.2 More...	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Cassidy, F.,2007	D12S2082, D12S2078	Multipoint Linkage Analysis: For marker D12S2082, Broad mode...... Multipoint Linkage Analysis: For marker D12S2082, Broad model, NPL = 1.78615, P-value = 0.037651; Pairwise Linkage Analysis: Broad model, NPL = 1.49254, P-value = 0.068397; For marker D12S2078, narrow model, NPL = 2.20186, P-value = 0.014663 More...	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Service, S.,2006	rs715447	Two point parametric linkage analysis: LOD = 1.2036 Two point parametric linkage analysis: LOD = 1.2036	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Degn, B.,2001	D12S76, D12S1349, D12S1612, D12S1614, D12S340, D12S1639, D12S324, D12S386, D12S1634, D12S307, D12S1658, GATA41E12, D12S1675, D12S1659, D12S97, D12S342, D12S2075	Single marker association: P-value(T1) = 0.007, P-value(T4) ...... Single marker association: P-value(T1) = 0.007, P-value(T4) = 0.007 for marker D12S342; P-value(T1) = 0.038, P-value(T4) = 0.034 for marker D12S2075 More...	Significant association was found . Significant association was found .	Positive

Region related genes (count: 24)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
HCAR2	hydroxycarboxylic acid receptor 2	12q24.31	1(0/1/0)
ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	12q24.11	2(0/2/0)
NOS1	nitric oxide synthase 1 (neuronal)	12q24.22	8(2/5/1)
RSRC2	arginine/serine-rich coiled-coil 2	12q24.31	2(1/1/0)
P2RX7	purinergic receptor P2X, ligand gated ion channel, 7	12q24	9(2/7/0)
SBNO1	strawberry notch homolog 1 (Drosophila)	12q24.31	1(0/1/0)
NCOR2	nuclear receptor corepressor 2	12q24	1(0/1/0)
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	12q24.12	3(3/0/0)
P2RX4	purinergic receptor P2X, ligand gated ion channel, 4	12q24.32	1(0/1/0)
PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	12q24.31	1(0/1/0)
CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	12q24.2	2(1/1/0)
ATP6V0A2	ATPase, H+ transporting, lysosomal V0 subunit a2	12q24.31	1(0/1/0)
DDX55	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	12q24.31	1(1/0/0)
CCDC92	coiled-coil domain containing 92	12q24.31	1(1/0/0)
PLA2G1B	phospholipase A2, group IB (pancreas)	12q24.31	4(1/3/0)
CIT	citron rho-interacting serine/threonine kinase	12q24.23	2(1/1/0)
KNTC1	kinetochore associated 1	12q24.31	1(0/1/0)
CLIP1	CAP-GLY domain containing linker protein 1	12q24.3	1(0/1/0)
CUX2	cut-like homeobox 2	12q24.12	3(1/2/0)
HCAR3	hydroxycarboxylic acid receptor 3	12q24.31	1(0/1/0)
FAM109A	family with sequence similarity 109, member A	12q24.12	1(1/0/0)
DAO	D-amino-acid oxidase	12q24.11	5(1/4/0)
LINC00939	long intergenic non-protein coding RNA 939	12q24.32	1(0/0/1)
IFT81	intraflagellar transport 81	12q24.13	1(0/0/1)

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