Gene Report

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Basic Info

Approved Symbol	FAM109A
Symbol Alias	FLJ32356
Approved Name	family with sequence similarity 109, member A
Location	12q24.12
Position	chr12:111360651-111369121, -1
External Links	HGNC: 26509 Entrez Gene: 144717 Ensembl: ENSG00000198324 UCSC: uc009zvu.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Glaser, B.,2005(b)	SNP: rs933399	In summary, we have provided evidence for association between BPD and polymorphisms in a small region of chromosome 12q23-q24 that includes the 30 end of the gene encoding CUX2 and a hypothetical protein, FLJ32356.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005802	trans-Golgi network	cellular component	IDA[21233288]	10
GO:0001881	receptor recycling	biological process	IMP[21233288]	1
GO:0007032	endosome organization	biological process	IMP[21233288]	2
GO:0030136	clathrin-coated vesicle	cellular component	IDA[21233288]	9
GO:0005515	protein binding	molecular function	IPI[21233288]	563
GO:0042147	retrograde transport, endosome to Golgi	biological process	IMP[21233288]	2
GO:0055037	recycling endosome	cellular component	IDA[21233288]	14
GO:0005769	early endosome	cellular component	IDA[21233288]	13
GO:0042803	protein homodimerization activity	molecular function	IPI[21233288]	71

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3840795	chr12:111363028 - 111363036(1)	downstream_gene_variant; inframe_deletion	1(1/0/0)
rs3809272	chr12:111362454 - 111362454(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs933399	chr12:111369695 - 111369695(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs10849938	chr12:111362255 - 111362255(1)	3_prime_UTR_variant; downstream_gene_variant
rs874286	chr12:111361877 - 111361877(1)	3_prime_UTR_variant; downstream_gene_variant
rs3742004	chr12:111360749 - 111360749(1)	3_prime_UTR_variant; downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q24	chr12:108600000-133275309	4 (1/1/2)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr12:111360651..111369121 View in gBrowse