SNP Report

Basic Info
Name rs4774388 dbSNP Ensembl
Location chr15:61174799 - 61174799(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.300919
Functional Annotation downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript downstream_gene_variant(ENST00000558904); intron_variant(ENST00000335670, ENST00000551975, ENST00000557822, ENST00000559145, ENST00000560300, ENST00000561093); NMD_transcript_variant(ENST00000551975); non_coding_transcript_variant(ENST00000557822, ENST00000559145, ENST00000560300, ENST00000561093)
No. of Studies 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Lai, Y. C., 2015 Empirical P-value=0.366; Empirical P-value=0.024 in sample I...... Empirical P-value=0.366; Empirical P-value=0.024 in sample I; OR=1.14; OR=1.53 in sample I More... In sample I, one marker each in the RORA and RORB genes show...... In sample I, one marker each in the RORA and RORB genes showed associations with BD (P<0.05). The minor allele of rs4774388 in RORA had an increased risk for BD. The marker did not show association with BD in Sample II. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
RORA RAR-related orphan receptor A 15q21-q22 3(2/1/0)

SNPs in LD with rs4774388 (count: 3) View in gBrowse (chr15:61165800..61177123 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)