SNP Report

Basic Info

Name	rs4774388 dbSNP Ensembl
Location	chr15:61174799 - 61174799(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.300919
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000558904); intron_variant(ENST00000335670, ENST00000551975, ENST00000557822, ENST00000559145, ENST00000560300, ENST00000561093); NMD_transcript_variant(ENST00000551975); non_coding_transcript_variant(ENST00000557822, ENST00000559145, ENST00000560300, ENST00000561093)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Lai, Y. C., 2015			Empirical P-value=0.366; Empirical P-value=0.024 in sample I...... Empirical P-value=0.366; Empirical P-value=0.024 in sample I; OR=1.14; OR=1.53 in sample I More...	In sample I, one marker each in the RORA and RORB genes show...... In sample I, one marker each in the RORA and RORB genes showed associations with BD (P<0.05). The minor allele of rs4774388 in RORA had an increased risk for BD. The marker did not show association with BD in Sample II. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
RORA	RAR-related orphan receptor A	15q21-q22	3(2/1/0)

SNPs in LD with rs4774388 (count: 3) View in gBrowse (chr15:61165800..61177123 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs1370433	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.841[CHD]; 0.908[JPT]
rs4775370	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CHB]; 1.0[JPT]
rs1816624	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 0.859[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)