BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	De bruyn, A.,1994 PMID: 7903509
Citation	De bruyn, A., K. Mendelbaum, et al. (1994). "Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11." Am J Psychiatry 151(1): 102-106.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Linkage study
Sample Size	14 families with 168 members
SNP/Region/Marker Size	whole genome wigde
Predominant Ethnicity
Population	Belgian,Jewish,Italian
Age Group	Mean age was 26.7 years (SD= 8.9), the range was 10-50 years

Detail Info

Other variants reported by this study for BD (count: 7)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
HARS TaqI Polymorphism	HARS	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
INS PvuII Polymorphism	INS	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
TYR (GA)n - (CA)n	TYR	duplication			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
DRD4 HincII Polymorphism	DRD4	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
TH PstI Polymorphism	TH	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
TH TaqI Polymorphism	TH	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
DRD2 TaqI Polymorphism	DRD2	SNP			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative

Genes reported by this study for BD (count: 6)

Gene	Statistical Values/Author Comments	Result Category
DRD4	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative
TH	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative
INS	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative
DRD2	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative
TYR	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative
HARS	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and nega...... Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions More...	Negative

Regions reported by this study for BD (count: 3)

Region	Statistical Values	Author Comments	Result Category
11p15		No significant linkage was found in this region No significant linkage was found in this region	Negative
11q14-q21		No significant linkage was found in this region No significant linkage was found in this region	Negative
11q22-q23		No significant linkage was found in this region No significant linkage was found in this region	Negative