BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Kirov, G.,1999(a) PMID: 10578238
Citation	Kirov, G., I. Jones, et al. (1999). "Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5." Mol Psychiatry 4(6): 558-565.
Disease Type	Bipolar I Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	122 parent-offspring trios
SNP/Region/Marker Size	6 variants
Predominant Ethnicity	Caucasian
Population	British
Gender	55 male and 67 female
Age Group	Adults : Probands had a mean age of 33.8, SD = 8.4 years. Their fathers had a mean age of 64.2, SD = 9.7 years, and the mothers: 61.9 years, SD = 9.4 years.

Detail Info

Other variants reported by this study for BD (count: 6)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
DRD5 (CT/GT/GA)n	DRD5	duplication	multi-alleles		TDT:chi square = 14.0, df = 12, P = 0.3	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DRD3 BalI Polymorphism	DRD3	point mutation			TDT:chi square = 0.27, 1 df, P = 0.6	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DRD2 141ins/del	DRD2	insertion/deletion	141ins/del		TDT:chi square = 0.03, P = 0.87	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
COMT Val158Met	COMT	point mutation	Val158Met		TDT:chi square = 0.08, P = 0.77	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DBH A304S	DBH	point mutation	A304S		TDT:chi square = 1.0,1 df, P = 0.31	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DAT VNTR	SLC6A3	VNTR	multi-alleles		TDT:chi square = 1.67, 2 df, P = 0.43	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative

Genes reported by this study for BD (count: 6)

Gene	Statistical Values/Author Comments	Result Category
COMT	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative
DRD5	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative
DRD3	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative
DBH	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative
SLC6A3	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative
DRD2	No statistically significant differences were found between transmitted and not transmitted alleles ...... No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. More...	Negative