BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Soeiro-de-Souza, M. G., 2013 PMID: 23072837
Citation	Soeiro-de-Souza, M. G., et al. (2013). "Bcl-2 rs956572 Polymorphism is Associated with Increased Anterior Cingulate Cortical Glutamate in Euthymic Bipolar I Disorder." Neuropsychopharmacology 38(3): 468-475.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	40 cases and 40 controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity
Gender	26 female cases, 19 female controls
Age Group	adults : 18-40 years

Detail Info

Sample Diagnosis	Structured Clinical Interview (SCID-I/P) for DSM-IV TR, DSM-IV
Sample Status	Forty euthymic-BD I subjects (26F) aged 18-40 years old were included in the study. Subjects with neurological disorders or medical disorders, head trauma, current substance abuse, or treated with electroconvulsive therapy in the last 6 months, were excluded.
Technique	genotyped for Bcl-2 rs956572 using real-time PCR allelic discrimination
Statistical Method	X² test was used for comparison of categorical data, and the ANOVA for continuous data. Results shown were corrected by Bonferroni post-hoc test for multiple variables. A significance level of Po0.05 was adopted and all analysis were performed using the IBM PASW 20.
Result Summary	Euthymic-BD subjects had higher Glu/Cre (creatine) and Glx/Cre compared with healthy controls. The Bcl-2 SNP AA genotype was associated with elevated ACC Glu/Cre and Glx/Cre ratio in the BD group but not in controls. The present study reports for the first time an increase in ACC Glu/Cre and Glx/Cre ratios in BD-euthymia. Also, Bcl-2 AA genotype, previously associated with lower Bcl-2 expression and increase intracellular Ca(2+), showed to be associated with increased ACC Glu and Glx levels in euthymic-BD subjects. The present findings reinforce a key role for glutamatergic system dysfunction in the pathophysiology of BD, potentially involving modulatory effects by Bcl-2 in the ACC.

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs956572	BCL2			allelic P-value=0.24, genotypic P-value=0.6	The Bcl-2 genotype distribution in the experimental sample w...... The Bcl-2 genotype distribution in the experimental sample was in accordance with the Hardy-Weinberg equilibrium, and genotype and allele A frequency did not differ between BD and control group. More...	Negative

Genes reported by this study for BD (count: 1)