Study Report
Basic Info
| Reference |
Shiino, Y.,2003 PMID: 12565145
|
| Citation |
Shiino, Y., S. Nakajima, et al. (2003). "Mutation screening of the human period 2 gene in bipolar disorder." Neurosci Lett 338(1): 82-84.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
88 patients with bipolar disorder and 127 normal controls |
| SNP/Region/Marker Size |
3 variants |
| Predominant Ethnicity |
Mongloid |
| Population |
Japanese |
| Gender |
Patients with bipolar disorder were 23 men and 65 women. The control subjects were 41 men and 86 women. |
| Age Group |
Adults
:
Mean age(SD)(year):47.3(14.1) for bipolar disorder cases ,26.6(10.0) for normal controls
|
Detail Info
| Sample Diagnosis |
DSM |
| Technique |
PCR and sequencing |
| Statistical Method |
Fisher's exact test with two-tailed probability was used to compare genotype distributions and allele frequencies between controls and patients with bipolar disorder. |
| Result Summary |
The frequencies of the S662G allele and genotypes on patients with bipolar disorder were very low and had no difference from those in controls. Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder. |
Other variants reported by this study for BD (count: 3)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| PER2 2087A/G |
PER2 |
point mutation |
A/G |
|
Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value > 0.05, allele P-value > 0.05
|
No significant association was observed in BD.
No significant association was observed in BD.
|
Negative
|
| PER2 2114G/A |
PER2 |
point mutation |
G/A |
|
Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value > 0.05, allele P-value > 0.05
|
No significant association was observed in BD.
No significant association was observed in BD.
|
Negative
|
| PER2 2117G/A |
PER2 |
point mutation |
G/A |
|
Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value > 0.05, allele P-value > 0.05
|
No significant association was observed in BD.
No significant association was observed in BD.
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| PER2 |
Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlike......
Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder.
More...
|
Negative
|
