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Reference | Gallitano, A. L.,2012 PMID: 22370066 |
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Citation | Gallitano, A. L., R. Tillman, et al. (2012). "Family-based association study of early growth response gene 3 with child bipolar I disorder." J Affect Disord 138(3): 387-396. |
Disease Type | Bipolar I Disorder |
Study Design | family-based |
Study Type | Candidate-gene association study |
Sample Size | 49 child BP-I families |
SNP/Region/Marker Size | 28 SNPs |
Predominant Ethnicity | |
Population | American |
Gender | 67.3% males |
Age Group | Adolescents : Mean age(SD)(year):10.9(2.8) |
Sample Diagnosis | DSM |
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Sample Status | Subjects met the inclusion criteria of 7 to 16 years old, males and females, good physical health, and a diagnosis of current DSM-IV BP-I (manic or mixed phase) for at least 2 weeks with at least 1 cardinal symptom of mania (i.e., elation and/or grandiosity) (Geller et al., 2008). A Children's Global Assessment Scale (CGAS) score of >= 60 was required to establish clinically significant impairment (Bird et al.,1987; Shaffer et al., 1983). DNA samples were previously collected, and isolated from whole blood, from a cohort of families of child BP-I patients (Geller et al., 2002b). |
Technique | Genotyping |
Statistical Method | Genotype data were analyzed using Family Based Association Test (FBAT) software. |
Result Summary | Two SNPs in EGR3 displayed nominally significant associations with child BP-I (p=0.027 and p=0.028); though neither was statistically significant following correction for multiple comparisons. Haplotype association analysis indicated that these SNPs are in linkage disequilibrium (LD). None of the SNPs tested in EGR1, EGR2, or EGR4 was associated with child BP-I. LIMITATIONS: This study was limited by small sample size, which resulted in it being underpowered to detect a significant association after correction for multiple comparisons. CONCLUSIONS: Our study revealed a preliminary finding suggesting that EGR3, a gene that translates environmental stimuli into long-term changes in the brain, warrants further investigation for association with risk for child BP-I disorder in a larger sample. Such studies may help reveal mechanisms by which environment can interact with genetic predisposition to influence this severe mental illness. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs6718289 | EGR4 RNU6-111P | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs4872533 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs4535741 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs4520160 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs7729723 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs6914 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs6747506 | EGR4 RNU6-111P | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs10095121 | EGR3 | C/T | Association analysis: FBAT, chi square=4.83, P-value = 0.028 | Significant association was observed in BPI. Significant association was observed in BPI. | Positive | |
rs10104039 | EGR3 | C/T | Association analysis: FBAT, chi square=4.90, P-value = 0.027 | Significant association was observed in BPI. Significant association was observed in BPI. | Positive | |
rs10128333 | EGR2 ADO | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs11741807 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1008949 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs17088536 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1548587 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1996147 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1800778 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs11775096 | PEBP4 EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs11743810 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1522928 | EGR4 RNU6-111P | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs1509963 | EGR2 ADO | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs3750192 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs2297488 | EGR2 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs4295666 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs3813224 | EGR4 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs2090052 | EGR3 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs2051861 | EGR1 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs2295814 | EGR2 ADO | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative | ||
rs2229294 | EGR4 | Association analysis: FBAT, P-value > 0.05 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|
rs10095121 - rs10104039 | T-C | EGR3 | Family-Based Haplotype Test:chi square=4.95, P-value = 0.026 | Significant association was observed in BPI. Significant association was observed in BPI. | Positive |
rs10095121 - rs10104039 | C-T | EGR3 | Family-Based Haplotype Test:chi square=6.06, P-value = 0.014 | Significant association was observed in BPI. Significant association was observed in BPI. | Positive |
rs10095121 - rs10104039 | T-T | EGR3 | Family-Based Haplotype Test:chi square=0, P-value = 0.966 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
rs10095121 - rs10104039 | C-C | EGR3 | Family-Based Haplotype Test:chi square=0.75, P-value = 0.387 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
Gene | Statistical Values/Author Comments | Result Category |
---|---|---|
EGR1 | None of the SNPs tested in EGR1 was associated with child BP-I. None of the SNPs tested in EGR1 was associated with child BP-I. | Negative |
EGR3 | Our study revealed a preliminary finding suggesting that EGR3, a gene that translates environmental ...... Our study revealed a preliminary finding suggesting that EGR3, a gene that translates environmental stimuli into long-term changes in the brain, warrants further investigation for association with risk for child BP-I disorder in a larger sample. More... | Positive |
EGR4 | None of the SNPs tested in EGR4 was associated with child BP-I. None of the SNPs tested in EGR4 was associated with child BP-I. | Negative |
EGR2 | None of the SNPs tested in EGR2 was associated with child BP-I. None of the SNPs tested in EGR2 was associated with child BP-I. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016