Study Report
Basic Info
| Reference |
Chen, S. L., 2014 PMID: 24468644
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| Citation |
Chen, S. L., et al. (2014). "The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia." Prog Neuropsychopharmacol Biol Psychiatry 51C: 99-104.
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| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
177 patients with bipolar I disorder, 190 with bipolar II disorder, 151 with schizophrenia and 126 healthy controls. |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Taiwanese |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
The Chinese version of the Schedule for Affective Disorders and Schizophrenia-Lifetime (SADS-L), which has good reliability and validity, was used to screen all participants' psychiatric conditions, to confirm that they fit DSM-IV diagnostic criteria, and to verify that the participants had no physical and mental comorbidities. Subjects who had sleep disorder, substance abuse, mood swing or possible psychiatric traits in life were first excluded from controls. |
| Technique |
PCR |
| Statistical Method |
One-way analysis of variance (ANOVA), and then the Tukey-Kramer Post-hoc test was used for statistical evaluations. A _2 test was used for categorical variables. |
| Result Summary |
the distribution of the BDNF Val66Met SNP was not different between schizophrenia, bipolar I disorder, bipolar II disorder and controls (_2 = 5.289, p = 0.507). |
Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| BDNF Val66Met |
BDNF |
point mutation |
Met/Val |
|
Genotype: P-value=0.155 for BP-1 patients, P-value=0.112 for BP-II patients. Alley frequency: P-value=0.249 for BP-1 patients, P-value=0.255 for BP-II patients.
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the distribution of the BDNF Val66Met SNP was not different ......
the distribution of the BDNF Val66Met SNP was not different between groups.
More...
|
Negative
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Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
| Disease |
Variant Name |
Related Gene |
Type |
Statistical Values |
Description |
Result Category |
| SZ |
BDNF Val66Met |
BDNF |
point mutation |
Genotype: P-value=0.373 for schizophrenia patients. Alley frequency: P-value=0.420 for schizophrenia patients. |
the distribution of the BDNF Val66Met SNP was not different between groups. |
Negative |
