Study Report
Basic Info
| Reference |
Nassan, M., 2015 PMID: 26528762
|
| Citation |
Nassan, M., et al. (2015). "Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder." Bipolar Disord 17(6): 645-652.
|
| Disease Type |
early-onset bipolar disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls |
| Predominant Ethnicity |
|
| Population |
from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank |
Detail Info
| Sample Diagnosis |
DSM-IV, DSM-IV-TR |
| Sample Status |
TEAM participants were outpatients [mean (standard deviation) age = 10.1 (2.8) years] with a diagnosis of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) BD type I, manic, or mixed episodes. Adult cases from the Mayo Clinic Bipolar Disorder Biobank included 855 participants with a diagnosis of BD according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) (DSM-IV-TR), aged 18–80 years at enrollment. Cases included participants with diagnoses of BD type I and BD type II. |
| Technique |
TEAM samples (n = 82) were genotyped with the TaqMan assay (Life Technologies, Carlsbad, CA, USA) at Washington University; adult BD cases (n = 855) and controls (n = 857) from the Mayo Biobanks were genotyped using the same TaqMan assay on an ABI 7900 HT instrument (Applied Biosystems, Carlsbad, CA, USA) at the Karolinska Institute. Ten adult BD cases from the Mayo Biobank were genotyped at Washington University with the TEAM EO-BD samples for quality control, obtaining 100% concordant genotype calls at the Karolinska Institute and Washington University for subjects genotyped in duplicate. |
| Statistical Method |
logistic regression assuming log-additive allele effect |
| Result Summary |
These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| BDNF Val66Met |
BDNF |
point mutation |
Val/Met |
|
|
Comparison of adult BD cases with controls provided nonsigni......
Comparison of adult BD cases with controls provided nonsignificant evidence of association of the minor Met allele of Val66Met with BD(OR = 1.19, p = 0.06). However, comparison of TEAM early-onset cases with controls showed a stronger association of the minor allele with EO-BD (OR = 1.55, p = 0.04). Although comparison of adult EO-BD cases from the Mayo Clinic BD Biobank with controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When early-onset adult BD cases from the Mayo BD Biobank and TEAM early-onset cases were together compared with the controls, the association of the minor allele of rs6265 with EO-BD was statistically significant (OR = 1.30, p = 0.04).
More...
|
Positive
|
