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KEGG Pathway Report
Basic Info
| ID | hsa04530 |
|---|---|
| Name | Tight junction |
| No. of Genes in BDgene | 18 |
| Source | Pathway by PBA |
PBA Result
| Pathway Name in Paper | Source | Reference | Data Set | Tool | Result Parameters | Result Link |
|---|---|---|---|---|---|---|
| Tight junction | PBA paper | Chen, L., 2009 | WTCCC | Prioritizing Risk Pathways fusing SNPs and pathways (PRP) | risk score=0.51 | |
| Tight junction | PBA paper | O'Dushlaine, C.,2011 | WTCCC | SNP ratio test | P-value=0.02; CAM and tight junction overlap at a molecular level and are involved in the same functions |
Pathway related genes in BDgene (count: 18)
| Approved Symbol | Approved Name | Location | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| EXOC4 | exocyst complex component 4 | 7q31 | 1(0/0/1) |
| MYH14 | myosin, heavy chain 14, non-muscle | 19q13.33 | 1(0/1/0) |
| PRKCZ | protein kinase C, zeta | 1p36.33-p36.2 | 1(1/0/0) |
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide | 20p13 | 2(0/2/0) |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 18p11.2 | 1(1/0/0) |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 3p14.1 | 1(1/0/0) |
| EXOC3 | exocyst complex component 3 | 5p15.33 | 1(1/0/0) |
| PARD6B | par-6 family cell polarity regulator beta | 20q13.13 | 1(0/0/1) |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 14q32.33 | 3(3/0/0) |
| CTTN | cortactin | 11q13 | 1(1/0/0) |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 10q21 | 1(1/0/0) |
| PRKCE | protein kinase C, epsilon | 2p21 | 1(0/1/0) |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 4p16.1 | 2(1/1/0) |
| JAM3 | junctional adhesion molecule 3 | 11q25 | 2(1/1/0) |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 3p21.31 | 1(0/1/0) |
| CLDN16 | claudin 16 | 3q28 | 1(0/1/0) |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 8p21.2 | 1(0/1/0) |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 7q21 | 1(1/0/0) |