SNP Report

Basic Info
Name rs2278637 dbSNP Ensembl
Location chr17:8158784 - 8158784(1)
Variant Alleles G/T
Ancestral Allele T
Minor Allele G
Minor Allele Frequence 0.364816
Functional Annotation downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000316509, ENST00000404970, ENST00000481878, ENST00000488857); intron_variant(ENST00000498285); upstream_gene_variant(ENST00000354903, ENST00000577253, ENST00000581395, ENST00000584202)
No. of Studies 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Abou Jamra, R, 2008 (b) G/T Initial sample: Armitage P-value = 0.005; Replication sampl...... Initial sample: Armitage P-value = 0.005; Replication sample: Armitage P-value = 0.716 More... We observed evidence of association with SNPs at the VAMP2 l...... We observed evidence of association with SNPs at the VAMP2 locus in the initial sample. We could not replicate our initial finding in the single-marker analysis, none of the analyses in our stratified subsamples showed any significant differences between cases and controls. More... Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
PER1 period circadian clock 1 17p13.1 5(2/3/0)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17p13.1 1(1/0/0)

SNPs in LD with rs2278637 (count: 8) View in gBrowse (chr17:8158784..8195865 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 8)

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)