BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Abou Jamra, R, 2008 (b) PMID: 18628682
Citation	Abou Jamra, R., C. M. Gobina, et al. (2008). "Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder." Psychiatr Genet 18(4): 199-203.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	409 BD and 407 controls
SNP/Region/Marker Size	3 SNP markers at the VAMP2 gene locus and 4 SNP markers at the VAMP3 locus
Predominant Ethnicity	Caucasian
Population	German
Gender	Initial sample included 409 BD patients (46.7% female and 53.3% male) and 407 controls (56.8% female and 43.2% male). Replication sample included 378 BD patients (46.6% female and 53.4% male) and 384 controls (56.3% female and 43.8% male)
Age Group	adults : BD patients in initial sample: mean age=43.3 (SD=11.5) years, controls in initial sample: mean age=51.2 (SD=13.5) years. BD patients in replication sample: mean age=44.0 (SD=11.0) years, controls in replication sample: mean age=50.8 (SD=13.2) years.

Detail Info

Sample Diagnosis	A comprehensive inventory for phenotype characterization - Interview for Psychiatric Genetic Studies. This included the Structured Clinical Interview of DSM IV Axis I Disorders Interview for Diagnostic and Statistical Manual Of Mental Disorder-IV and the OPerational CRITeria system as well as review of medical records.
Sample Status	patients from the initial sample showed a higher prevalence of psychotic symptoms (occurrence of hallucinations and/or delusions according to Operational CRITeria), persecutory delusions, suicide attempts, and irritable mood.
Replication Size	378 BD and 384 controls
Technique	Genotyping was carried out using TaqMan technology
Statistical Method	Departure from Hardy-Weinberg-equilibrium was tested using a X²- test (1df). Single-marker association analysis was performed using the Cochrane-Armitage Trend Test. Power calculations were conducted with the Genetic Power Calculator. The haplotype distributions of cases and controls were compared using FAMHAP. All marker combinations were tested according to Becker et al. (2005a) and a global P value to correct for multiple testing was computed using Monte-Carlo simulations.
Result Summary	Although no association was found for VAMP3 markers, we observed evidence of association with SNPs at the VAMP2 locus in the initial sample (P values between 0.005 and 0.033). To validate these findings, we analyzed a second BPAD sample and failed to replicate the initial findings at the single-marker and haplotypic level. Our results do not suggest that a common genetic variant at VAMP2 or VAMP3 contributes to the development of bipolar affective disorder in German patients.

SNPs reported by this study for BD (count: 6)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs228729	VAMP3 PER3	A/G		Initial sample: Armitage P-value = 0.929;	none of the four analyzed SNP markers revealed significant a...... none of the four analyzed SNP markers revealed significant association to bipolar affective disorder More...	Negative
rs2278637	VAMP2 PER1	G/T		Initial sample: Armitage P-value = 0.005; Replication sample: Armitage P-value = 0.716	We observed evidence of association with SNPs at the VAMP2 l...... We observed evidence of association with SNPs at the VAMP2 locus in the initial sample. We could not replicate our initial finding in the single-marker analysis, none of the analyses in our stratified subsamples showed any significant differences between cases and controls. More...	Positive
rs2071987	VAMP3 CAMTA1	A/G		Initial sample: Armitage P-value = 0.728;	none of the four analyzed SNP markers revealed significant a...... none of the four analyzed SNP markers revealed significant association to bipolar affective disorder More...	Negative
rs8067606	VAMP2	A/G		Initial sample: Armitage P-value = 0.007; Replication sample: Armitage P-value = 0.461	We observed evidence of association with SNPs at the VAMP2 l...... We observed evidence of association with SNPs at the VAMP2 locus in the initial sample. We could not replicate our initial finding in the single-marker analysis, none of the analyses in our stratified subsamples showed any significant differences between cases and controls. More...	Positive
rs707455	CAMTA1 VAMP3	C/T		Initial sample: Armitage P-value = 0.899;	none of the four analyzed SNP markers revealed significant a...... none of the four analyzed SNP markers revealed significant association to bipolar affective disorder More...	Negative
rs2301489	VAMP3	C/G		Initial sample: Armitage P-value = 0.650;	none of the four analyzed SNP markers revealed significant a...... none of the four analyzed SNP markers revealed significant association to bipolar affective disorder More...	Negative

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2278637 - rs8067606		VAMP2	For initial sample, corrected global P-value = 0.013, the strongest association was obtained for the haplotype G-A at markers rs2278637-rs8067606, which occurred with a frequency of 35.8% in patients and 29.2% in controls. For replication sample, global P-value = 0.018, haplotype G-G (at rs2278637-rs8067606), which showed opposite tendencies in the initial sample. The former observed risk-haploypte G-A at the same marker combination occurred more frequently in controls (34.0%) compared with the patients (31.9%) in the replication sample. For combined sample, global P-value = 0.252	none of the analyses in our stratified subsamples showed any...... none of the analyses in our stratified subsamples showed any significant differences between cases and controls More...	Positive

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
VAMP2 C 25610873 10	VAMP2	point mutation	C/G		not given in the original text	We observed evidence of association with SNPs at the VAMP2 l...... We observed evidence of association with SNPs at the VAMP2 locus in the initial sample. We could not replicate our initial finding in the single-marker analysis, none of the analyses in our stratified subsamples showed any significant differences between cases and controls. More...	Positive

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
VAMP2	We could not replicate our initial finding in the single-marker analysis. Our results do not suggest...... We could not replicate our initial finding in the single-marker analysis. Our results do not suggest that a common genetic variant at VAMP2 contributes to the development of BD in German patients. More...	Positive
VAMP3	our results do not suggest that a common genetic variant at VAMP3 contributes to the development of ...... our results do not suggest that a common genetic variant at VAMP3 contributes to the development of BD in German patients More...	Negative