SNP Report

Basic Info

Name	rs8067606 dbSNP Ensembl
Location	chr17:8163465 - 8163465(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.366613
Functional Annotation	splice_donor_variant; upstream_gene_variant.
Consequence to Transcript	splice_donor_variant(ENST00000404970); upstream_gene_variant(ENST00000316509, ENST00000481878, ENST00000488857, ENST00000498285)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Abou Jamra, R, 2008 (b)	A/G		Initial sample: Armitage P-value = 0.007; Replication sampl...... Initial sample: Armitage P-value = 0.007; Replication sample: Armitage P-value = 0.461 More...	We observed evidence of association with SNPs at the VAMP2 l...... We observed evidence of association with SNPs at the VAMP2 locus in the initial sample. We could not replicate our initial finding in the single-marker analysis, none of the analyses in our stratified subsamples showed any significant differences between cases and controls. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	17p13.1	1(1/0/0)

SNPs in LD with rs8067606 (count: 8) View in gBrowse (chr17:8158881..8195865 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs12941873	upstream_gene_variant	0.87[CEU]; 0.976[TSI]
rs9899533	upstream_gene_variant	0.871[CEU]; 0.976[TSI]
rs9891949	downstream_gene_variant; upstream_gene_variant	0.908[CEU]; 0.951[TSI]
rs12051754	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs8069739	3_prime_UTR_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs1150	3_prime_UTR_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs8064449	intron_variant; non_coding_transcript_variant; stop_gained; upstream_gene_variant	0.871[CEU]; 0.976[TSI]
rs959303	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)