Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Cuellar-Barboza, A. B., 2016 PMID: 26934194
Citation	Cuellar-Barboza, A. B., et al. (2016). "Accumulating evidence for a role of TCF7L2 variants in bipolar disorder with elevated body mass index." Bipolar Disord.
Disease Type	Bipolar disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	662 BD cases and 616 controls
SNP/Region/Marker Size	26 SNPs
Predominant Ethnicity
Population	European
Gender	271 (40.9%) male for cases; 248 (40.3) male for controls
Age Group	adults : mean age (SD) = 42.5 (15.2) years for cases; mean age (SD) = 42.7 (14.4) years for controls

Detail Info

Sample Diagnosis	DSM-IV/ICD9
Sample Status	Subjects who reported a prior diagnosis of BD, schizophrenia, major depression, Down syndrome, autism, attention-deficit hyperactivity disorder, or other psychiatric conditions, and those who reported having a first-degree relative with BD, were excluded from the control group.
Technique	Genotyping was performed using the Illumina GoldenGate Platform.
Statistical Method	Logistic regression models
Result Summary	The current study provides further evidence suggesting that TCF7L2 involvement in BD risk may be regulated by BMI. Detailed, prospective assessment of BMI, comorbidity, and other possible contributing factors is necessary to explain fully the mechanisms underlying this association.

SNPs reported by this study for BD (count: 26)

SNP	Related Gene(s)	Risk Allele	Statistical Values	Author Comments	Result Category
rs3750805	TCF7L2	A	SNP main effect: P-value=0.7,Â OR=0.96; SNP-BMI interaction: P-value=0.020,Â OR=0.96	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs4132670	TCF7L2	A	SNP main effect: P-value=0.61,Â OR=1.04; SNP-BMI interaction: P-value=0.049,Â OR=1.03	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs7895307	TCF7L2	A	SNP main effect: P-value=0.5,Â OR=0.95; SNP-BMI interaction: P-value=0.006,Â OR=0.97	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs7917983	TCF7L2	G	SNP main effect: P-value=0.87,Â OR=1.01; SNP-BMI interaction: P-value=0.021,Â OR=1.03	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs290484	TCF7L2	C	SNP main effect: P-value=0.79,Â OR=1.03; SNP-BMI interaction: P-value=0.033,Â OR=0.96	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs10787476	TCF7L2	C	SNP main effect: P-value=0.44,Â OR=0.9; SNP-BMI interaction: P-value=0.016,Â OR=1.08	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs12772424	TCF7L2	T	SNP main effect: P-value=1,Â OR=0.67; SNP-BMI interaction: P-value=0.011,Â OR=1.04	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive
rs6585209	TCF7L2	G	SNP main effect: P-value=0.32,Â OR=1.08; SNP-BMI interaction: P-value=0.11,Â OR=1.02	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs290475	TCF7L2	G	SNP main effect: P-value=0.24,Â OR=0.9; SNP-BMI interaction: P-value=0.1,Â OR=1.03	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs11196229	TCF7L2	A	SNP main effect: P-value=0.28,Â OR=1.09; SNP-BMI interaction: P-value=0.21,Â OR=1.02	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs7085532	TCF7L2	G	SNP main effect: P-value=0.086,Â OR=0.87; SNP-BMI interaction: P-value=0.43,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs1885510	TCF7L2	G	SNP main effect: P-value=0.92,Â OR=1.01; SNP-BMI interaction: P-value=0.13,Â OR=1.02	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs290487	TCF7L2	A	SNP main effect: P-value=0.2,Â OR=1.13; SNP-BMI interaction: P-value=0.19	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs7919185	TCF7L2	G	SNP main effect: P-value=0.44,Â OR=1.06; SNP-BMI interaction: P-value=0.15,Â OR=1.02	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs1362943	TCF7L2	A	SNP main effect: P-value=0.98,Â OR=1; SNP-BMI interaction: P-value=0.94,Â OR=1	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs7924080	TCF7L2	G	SNP main effect: P-value=0.42,Â OR=1.06; SNP-BMI interaction: P-value=0.46,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs11196201	TCF7L2	T	SNP main effect: P-value=0.15,Â OR=0.82; SNP-BMI interaction: P-value=0.71,Â OR=0.99	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs11196203	TCF7L2	A	SNP main effect: P-value=0.47,Â OR=1.08; SNP-BMI interaction: P-value=0.73,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs12255372	TCF7L2	A	SNP main effect: P-value=0.47,Â OR=1.06; SNP-BMI interaction: P-value=0.32,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs7087006	TCF7L2	G	SNP main effect: P-value=0.7,Â OR=1.03; SNP-BMI interaction: P-value=0.36,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs3750804	TCF7L2	A	SNP main effect: P-value=0.6,Â OR=1.04; SNP-BMI interaction: P-value=0.65,Â OR=0.99	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs12184389	TCF7L2	A	SNP main effect: P-value=0.53,Â OR=1.06; SNP-BMI interaction: P-value=0.11,Â OR=0.97	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs11196224	TCF7L2	A	SNP main effect: P-value=0.31,Â OR=1.09; SNP-BMI interaction: P-value=0.62,Â OR=0.99	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs6585194	TCF7L2	G	SNP main effect: P-value=0.26,Â OR=0.91; SNP-BMI interaction: P-value=0.7,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs6585195	TCF7L2	C	SNP main effect: P-value=0.86,Â OR=1.02; SNP-BMI interaction: P-value=0.13,Â OR=1.03	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative
rs11196175	TCF7L2	G	SNP main effect: P-value=0.63,Â OR=0.96; SNP-BMI interaction: P-value=0.45,Â OR=1.01	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs7895307 - rs12772424	G-T	TCF7L2	P-value=0.0008	Haplotype analysis of the two SNPs with strongest evidence f...... Haplotype analysis of the two SNPs with strongest evidence for association with BD via BMI interaction in the sample analyzed in the present study and the GAIN data demonstrated that the rs7895307 G-rs12772424 T haplotype is associated with a greater risk for BD as BMI increases. More...

Genes reported by this study for BD (count: 1)