SNP Report

Basic Info

Name	rs4132670 dbSNP Ensembl
Location	chr10:113008012 - 113008012(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.342252
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000346198, ENST00000352065, ENST00000355717, ENST00000355995, ENST00000369395, ENST00000369397, ENST00000534894, ENST00000536810, ENST00000538897, ENST00000542695, ENST00000543371, ENST00000545257, ENST00000627217, ENST00000629706)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cuellar-Barboza, A. B., 2016		A	SNP main effect: P-value=0.61,Â OR=1.04; SNP-BMI interaction...... SNP main effect: P-value=0.61,Â OR=1.04; SNP-BMI interaction: P-value=0.049,Â OR=1.03 More...	Seven out of the 26 genotyped TCF7L2 SNPs showed a significa...... Seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	10q25.3	1(1/0/0)

SNPs in LD with rs4132670 (count: 4) View in gBrowse (chr10:112994329..113025665 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs7903146	intron_variant	0.897[CEU]; 0.953[TSI]
rs7074440	intron_variant	0.847[CEU]; 0.952[TSI]
rs4506565	intron_variant	1.0[CEU]; 0.953[TSI]
rs7901695	intron_variant	0.948[CEU]; 0.928[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)