SNP Report

Basic Info

Name	rs7085532 dbSNP Ensembl
Location	chr10:113099704 - 113099704(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	G
Minor Allele Frequence	0.345248
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000346198, ENST00000352065, ENST00000355717, ENST00000355995, ENST00000369395, ENST00000369397, ENST00000534894, ENST00000536810, ENST00000538897, ENST00000542695, ENST00000543371, ENST00000545257, ENST00000627217, ENST00000629706)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cuellar-Barboza, A. B., 2016		G	SNP main effect: P-value=0.086,Â OR=0.87; SNP-BMI interactio...... SNP main effect: P-value=0.086,Â OR=0.87; SNP-BMI interaction: P-value=0.43,Â OR=1.01 More...	Consistent with the discovery study, the SNPs showed no marg...... Consistent with the discovery study, the SNPs showed no marginal effect on BD risk, either unadjusted or adjusted for BMI (all p > 0.05); however, seven out of the 26 genotyped TCF7L2 SNPs showed a significant SNPâ€“BMI interaction effect, with p < 0.05. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	10q25.3	1(1/0/0)

SNPs in LD with rs7085532 (count: 1) View in gBrowse (chr10:113099405..113099704 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs6585205		intron_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)