Study Report
Basic Info
| Reference |
Forero, D. A., 2016 PMID: 26899345
|
| Citation |
Forero, D. A., et al. (2016). "A network of synaptic genes associated with schizophrenia and bipolar disorder." Schizophr Res.
|
| Disease Type |
schizophrenia, bipolar disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study (convergent genomic data analysis) |
| Sample Size |
486 SZ, 351 BP patients and 514 control individuals |
| SNP/Region/Marker Size |
48 SNPs |
| Predominant Ethnicity |
Caucasians |
| Population |
Northern Sweden |
| Gender |
47.2% male for BP patients, 65.3% male for SZ patients |
| Age Group |
adults
:
mean age = 56.3 years for BP patients, mean age = 58.5 years for SZ patients
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
Patients were evaluated by experienced psychiatrists and diagnosis was made according to DSM-IV criteria. |
| Technique |
The genotyping of all SNPs was performed using the MassARRAY iPLEX Gold technology (SequenomInc., San Diego, California), following the protocol provided by Sequenom (http://www.sequenom.com). |
| Statistical Method |
The PLINK and UNPHASED programs (Dudbridge, 2008; Purcell et al., 2007) were used for Hardy–Weinberg equilibrium (HWE) analysis, patient-control comparisons of single SNPs (using a X2 test) and haplo- type analysis (using 1000 permutations). |
| Result Summary |
Our results highlight the feasibility and the importance of convergent genomic data analysis for the identification of candidate genes and our data provide support for the role of common inherited variants in synaptic genes and their involvement in the etiology of BP and SZ. |
SNPs reported by this study for BD (count: 4)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs4968898 |
PRKAR1A
|
|
|
Nominal P-value=0.008651, Permutation P-value=0.008991, OR=0.6798, 95%CI=0.5091-0.9079
|
Allelic association analysis showed significant results for ......
Allelic association analysis showed significant results for the BP sample with a SNP in PPP3CB (rs12775630; p = 0008) and PRKAR1A (rs4968898; p=0009).
More...
|
Positive
|
| rs3793663 |
PPP3CB
USP54
|
|
|
Nominal P-value=0.03831, Permutation P-value=0.0396, OR=0.4432, 95%CI=0.2012-0.9764
|
rs3793663 is significantly associated with BP type II
rs3793663 is significantly associated with BP type II
|
Positive
|
| rs12775630 |
PPP3CB
|
|
|
Nominal P-value=0.001932, Permutation P-value=0.007992, OR=2.097, 95%CI=1.301-3.381
|
Allelic association analysis showed significant results for ......
Allelic association analysis showed significant results for the BP sample with a SNP in PPP3CB (rs12775630; p = 0008) and PRKAR1A (rs4968898; p=0009).
More...
|
Positive
|
| rs9893241 |
TMEM104
GRIN2C
|
|
|
Nominal P-value=0.02096, Permutation P-value=0.009901, OR=0.2164, 95%CI=0.05196-0.9013
|
rs9893241 is significantly associated with BP patients with ......
rs9893241 is significantly associated with BP patients with an earlier onset.
More...
|
Positive
|
Genes reported by this study for BD (count: 3)
| Gene |
Statistical Values/Author Comments |
Result Category |
| PRKAR1A |
P-value=0.03.
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed signific......
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed significant associations with NF1 (p=0,01), PPP3CB (p=0005) and PRKAR1A (p=0,03) in the total BP and SZ samples.
More...
|
Positive
|
| NF1 |
P-value=0.01.
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed signific......
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed significant associations with NF1 (p=0,01), PPP3CB (p=0005) and PRKAR1A (p=0,03) in the total BP and SZ samples.
More...
|
Positive
|
| PPP3CB |
P-value=0.005.
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed signific......
HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed significant associations with NF1 (p=0,01), PPP3CB (p=0005) and PRKAR1A (p=0,03) in the total BP and SZ samples.
More...
|
Positive
|
