Study Report
Basic Info
| Reference |
Dawson, E.,1995 PMID: 8750360
|
| Citation |
Dawson, E., M. Gill, et al. (1995). "Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder." Psychiatr Genet 5(4): 177-180.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
54 cases and 56 controls |
| SNP/Region/Marker Size |
7 microsatellite polymorphisms |
| Predominant Ethnicity |
|
| Population |
European |
| Gender |
11 males, 43 females in cases and 16 males, 34 females, 6 unrecorded in controls |
Detail Info
| Sample Diagnosis |
RDC |
| Sample Status |
All patients were diagnosed using SADS-L and RDC for bipolar disorder. The controls, matched for ethnic origin and age, were selected from attenders at King's college Hospital haematology clinic. The psychiatric status of the control subjects was not assessed. |
| Technique |
PCR and DNA hybridization |
| Statistical Method |
chi-square tests |
| Result Summary |
Allele 122 bp was more common in controls (X2 = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X2 = 5.62, df = 1, P-value = 0.02). Of the 7 markers , PLA2A shows significant association with bipolar disorder. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| PLA2G1B microsatellite polymorphisms |
PLA2G1B |
microsatellite |
|
|
Allele 122 bp was more common in controls (X2 = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X2 = 5.62, df = 1, P-value = 0.02).
|
Result suggested a association of this variant with BD
Result suggested a association of this variant with BD
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| PLA2G1B |
Allele 122 bp was more common in controls (X<sup>2</sup> = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X<sup>2</sup> = 5.62, df = 1, P-value = 0.02)..
PLA2A shows significant association with bipolar disorder.
PLA2A shows significant association with bipolar disorder.
|
Positive
|
Regions reported by this study for BD (count: 1)
| Region |
Statistical Values |
Author Comments |
Result Category |
| 12q |
Allele 122 bp was more common in controls (X2 = 8.85, df = 1, P-value = 0.003) and allele 134 bp was more common in cases (X2 = 5.62, df = 1, P-value = 0.02). Of the 7 markers , PLA2A shows significant association with bipolar disorder.
|
PLA2A shows significant association with bipolar disorder in......
PLA2A shows significant association with bipolar disorder in this region
More...
|
Positive
|
