BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Meira-Lima, I.,2003(a) PMID: 12895207
Citation	Meira-Lima, I., D. Jardim, et al. (2003). "Allelic association study between phospholipase A2 genes and bipolar affective disorder." Bipolar Disord 5(4): 295-299.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	181 unrelated BPAD subjects and 312 controls
SNP/Region/Marker Size	3 variants
Predominant Ethnicity
Population	Brazilian
Gender	Male/female:69/112 for BPAD patients and 146/166 for controls
Age Group	Adults : Mean age(SD)(year):43(12),21.8(7) at onset for BPAD patients and 36(9) for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	BPAD patients. A total of 181 unrelated patients with BPAD aged between 18 and 80 years were recruited from public psychiatric assistance services in the Sao Paulo city metropolitan area. All patients who fulfilled the DSMIIIR criteria for BPAD were selected for the study. All patients had at least one manic episode, and the mean number of episodes was eight, 79% of the patients had a history of psychotic symptoms.Venous blood samples were collected after written informed consent was obtained. Controls. A total of 312 control subjects aged between 18 and 60 years were selected from unrelated subjects admitted to the Blood Donation Center of the Fundac?a?o Pro_ -Sangue ?Sao Paulo University Medical School, after an interview to exclude those with a personal or family history of mental illness. An attempt to match both groups according to ethnicity was based on phenotypic characteristics (pigmentation of the abdomen, hair color and type and conformation or the nose and lips) and known family origin. The ethnic distribution of both groups was as follows: 60% Caucasian, 34% mulatto and 6% black.
Technique	PCR,RFLP and electrophoresis
Statistical Method	Allelic and genotypic frequencies of polymorphism on cPLA2 and iPLA2 genes were analyzed among BPAD patients and the control group using the chi-square test (statistical software Epi-Info version 6.0, Atlanta, GA, USA). The distribution of repeat marker alleles on the sPLA2 gene was compared between patients and controls using the CLUMP program (London,UK).
Result Summary	There was no significant difference observed in the allelic and genotypic distribution between the BPAD and control groups for cPLA2 (genotype: chi2 = 0.8, 2df, p = 0.6; allele chi2 = 0, 1df, p = 0.9), iPLA2 (genotype: chi2 = 1.7, 2df, p = 0.4; allele: chi2 = 0.3, 1df, p = 0.6), and sPLA2 (allele: chi2 = 3.6, 6df, p = 0.8).CONCLUSION: Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.

Other variants reported by this study for BD (count: 3)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
iPLA2 C/T	PLA2G6	point mutation	C/T		Association analysis:chi square test, genotype: X²=1.7, 2df, p?0.4; allele: X²=0.3, 1df, P-value = 0.6).	No significant association was observed in BD. No significant association was observed in BD.	Negative
cPLA2 BanI dimorphic site	KAT5	point mutation			Association analysis:chi square test, genotype: X²=0.8, 2df, P-value = 0.6; allele X²=0.0, 1df, P-value = 0.9	No significant association was observed in BD. No significant association was observed in BD.	Negative
PLA2G10 (AAT)n	PLA2G10	microsatellite	multi-allelic repeats		Association analysis: X²=4.7, 6df, P-value = 0.58	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
PLA2G6	Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increa...... Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample. More...	Negative
PLA2G1B	Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increa...... Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample. More...	Negative
KAT5	Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increa...... Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample. More...	Negative