BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Wang, Z., 2013 PMID: 23315174
Citation	Wang, Z., et al. (2013). "Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Gene Associated with Treatment Response to Mood Stabilizers in Patients with Bipolar I Disorder." J Mol Neurosci.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	284 cases and 295 controls
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	127 male and 157 female cases, 134 male and 161 female controls
Age Group	adults : The mean age of cases was 34.41, SD=13.56 years; The mean age for the controls was 33.83, SD=10.39 years.

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All BP I patients were recruited from those who were admitted to the Division of Mood Disorders at Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, from November 2006 to October 2010. The mean age of first episode was 26.03 (SD=9.61) years.
Technique	Genotyping was performed with TaqMan genotyping assay on an ABI PRISM 7900 Sequence Detection System.
Statistical Method	The _² test for goodness of fit was used to check for Hardy-Weinberg equilibrium in genotype distributions in patients and controls. For the case-control genetic comparisons, differences in the genotype and allele distributions between patients and controls were examined using Pearson's _² test. Bonferroni's adjustment was used for multiple comparisons. The adjusted P value for significance was set at 0.05/3=0.017.
Result Summary	Our study showed a significant allelic association between NTRK2 gene polymorphism rs2769605 and treatment response to mood stabilizers in BP I patients (t = -2.53, P = 0.01). However, no significant association between NTRK2 gene polymorphisms and BP I susceptibility was observed after correcting for multiple comparisons. The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients.

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2769605	NTRK2	G/A		allelic P-value=0.648, OR (95 % CI)=0.94 (0.71, 1.24), X²=0.209, df=1; genotypic P-value=0.307, X²=2.364, df=2	For SNP rs2769605, the allele or genotype frequencies of BP ...... For SNP rs2769605, the allele or genotype frequencies of BP I patients did not significantly differ from the controls. More...	Negative
rs1565445	NTRK2	C/T		allelic P-value=0.579, OR (95 % CI)=0.93 (0.73, 1.19), X²=0.308, df=1; genotypic P-value=0.821, X²=0.394, df=2	For SNP rs1565445, the allele or genotype frequencies of BP ...... For SNP rs1565445, the allele or genotype frequencies of BP I patients also did not significantly differ from the controls. More...	Negative
rs1387923	NTRK2	T/C		allelic P-value=0.034, OR (95 % CI)=1.33 (1.02, 1.74), X²=4.492, df=1; genotypic P-value=0.125, X²=4.166, df=2	For SNP rs1387923, the genotype frequency of BP I patients d...... For SNP rs1387923, the genotype frequency of BP I patients did not significantly differ from the controls, but the allele frequency of BP I patients was nominally significantly different from the controls. The T allele was significantly associated with increased risk for BP I disorder with an OR of 1.33. However, this association did not remain significant after Bonferroni correction for multiple comparisons. More...	Positive

Genes reported by this study for BD (count: 1)