SNP Report

Basic Info

Name	rs1387923 dbSNP Ensembl
Location	chr9:85025721 - 85025721(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.428914
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000277120); downstream_gene_variant(ENST00000323115, ENST00000376213, ENST00000376214)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Wang, Z., 2013	T/C		allelic P-value=0.034, OR (95 % CI)=1.33 (1.02, 1.74), X allelic P-value=0.034, OR (95 % CI)=1.33 (1.02, 1.74), X²=4.492, df=1; genotypic P-value=0.125, X²=4.166, df=2 More...	For SNP rs1387923, the genotype frequency of BP I patients d...... For SNP rs1387923, the genotype frequency of BP I patients did not significantly differ from the controls, but the allele frequency of BP I patients was nominally significantly different from the controls. The T allele was significantly associated with increased risk for BP I disorder with an OR of 1.33. However, this association did not remain significant after Bonferroni correction for multiple comparisons. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	3(1/1/1)

SNPs in LD with rs1387923 (count: 6) View in gBrowse (chr9:85001342..85032539 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs11140831		1.0[JPT]
rs1948308	intron_variant	1.0[JPT]
rs10115908	intron_variant	0.834[CHB]; 1.0[JPT]
rs7036090	intron_variant	1.0[JPT]
rs2378676	intron_variant	1.0[JPT]
rs10125141	intron_variant	0.822[CHB]; 0.921[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)