Study Report

Reference	Vogt, I. R.,2000 PMID: 10893499
Citation	Vogt, I. R., D. Shimron-Abarbanell, et al. (2000). "Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia." Am J Med Genet 96(2): 217-221.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	45 bipolar affective patients, 46 schizophrenic patients,and 46 unrelated controls
SNP/Region/Marker Size	6 variants
Predominant Ethnicity	Caucasian
Population	German

Sample Diagnosis	DSM
Technique	PCR and RFLP
Statistical Method	We applied Fisher's exact test (two-tailed) for comparing genotype distributions and allele frequencies between affected and control individuals from the screening sample. The transmission disequilibrium test (TDT) [Spielman et al., 1993] was applied for analysis of parent-offspring trios.
Result Summary	Comparing frequencies between patients and controls, we observed a significant overrepresentation of the 267C allele among bipolar patients (P=0. 023 not corrected for multiple testing). This finding was followed up in an independent sample of 105 bipolar family trios using a family-based association design. Fifty-one transmissions could be examined. In 30 cases allele 267C and in 21 cases allele 267T were transmitted to the affected offspring. Although this result was far from statistical significance (transmission disequilibrium test=1.59, P=0.208), the limited number of possible transmissions may have prevented detection of smaller effects. Our preliminary data suggest that bipolar affective disorder may be associated with variation in the 5-HT(6) gene. It will be important to extend the present analysis to larger samples.