Study Report

Basic Info
Reference |
Vogt, I. R.,2000 PMID: 10893499
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Citation |
Vogt, I. R., D. Shimron-Abarbanell, et al. (2000). "Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia." Am J Med Genet 96(2): 217-221.
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Disease Type |
Bipolar Disorder & Schizophrenia |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
45 bipolar affective patients, 46 schizophrenic patients,and 46 unrelated controls |
SNP/Region/Marker Size |
6 variants |
Predominant Ethnicity |
Caucasian |
Population |
German |

Detail Info
Sample Diagnosis |
DSM |
Technique |
PCR and RFLP |
Statistical Method |
We applied Fisher's exact test (two-tailed) for comparing genotype distributions and allele frequencies between affected and control individuals from the screening sample. The transmission disequilibrium test (TDT) [Spielman et al., 1993] was applied for analysis of parent-offspring trios. |
Result Summary |
Comparing frequencies between patients and controls, we observed a significant overrepresentation of the 267C allele among bipolar patients (P=0. 023 not corrected for multiple testing). This finding was followed up in an independent sample of 105 bipolar family trios using a family-based association design. Fifty-one transmissions could be examined. In 30 cases allele 267C and in 21 cases allele 267T were transmitted to the affected offspring. Although this result was far from statistical significance (transmission disequilibrium test=1.59, P=0.208), the limited number of possible transmissions may have prevented detection of smaller effects. Our preliminary data suggest that bipolar affective disorder may be associated with variation in the 5-HT(6) gene. It will be important to extend the present analysis to larger samples. |

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 4)
Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
HTR6 267C/T |
HTR6 |
point mutation |
C/T |
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Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value = 0.0015, allele P-value = 0.023;TDT=1.59 (P-value = 0.208).
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Significant association was found in BPD patients.
Significant association was found in BPD patients.
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Positive
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HTR6 873+128A/C |
HTR6 |
point mutation |
A/C |
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Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value = 0.024, allele P-value = 0.249
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Significant association was found in BPD patients.
Significant association was found in BPD patients.
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Positive
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HTR6 126G/T |
HTR6 |
point mutation |
G/T |
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Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value = 0.111, allele P-value = 0.118
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No significant association was observed in BD.
No significant association was observed in BD.
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Negative
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HTR6 873+30C/T |
HTR6 |
point mutation |
C/T |
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Assocaition analysis:Fisher's exact test, two-tailed, genotype P-value = 0.495, allele P-value = 0.495
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No significant association was observed in BD.
No significant association was observed in BD.
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Negative
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Genes reported by this study for BD (count: 1)
Gene |
Statistical Values/Author Comments |
Result Category |
HTR6 |
Our preliminary data suggest that bipolar affective disorder may be associated with variation in the......
Our preliminary data suggest that bipolar affective disorder may be associated with variation in the 5-HT(6) gene.
More...
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Positive
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Genetic factors reported by this study for SZ and/or MDD