BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Breen, G., 2006 PMID: 16946192
Citation	Breen, G., D. Prata, et al. (2006). "Association of the dysbindin gene with bipolar affective disorder." Am J Psychiatry 163(9): 1636-1638.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	213 patients and 197 controls
SNP/Region/Marker Size	10 SNPs
Predominant Ethnicity	Caucasian
Population	Scottish

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Subjects were recruited through psychiatric hospitals in Scotland, met DSM-IV criteria for bipolar I disorder, and had been receiving lithium therapy for at least 3 years. Patients with schizoaffective disorder were excluded.
Technique	Genotyping was conducted using KBiosciences, with a competitive allele specific polymerase chain reaction system.
Statistical Method	Power analysis was performed using the genetic power calculator. Statistical analysis was performed using both chi-square and Fisher's exact test to analyze individual polymorphisms. GENECOUNTING software was used to estimate the haplotype frequencies (with 1,000 permutations/simulations).
Result Summary	Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.

SNPs reported by this study for BD (count: 10)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs760761	DTNBP1			P-value < 0.04, OR=0.33, 95% CI=0.12-0.93, X²=4.39, df=1	Under this recessive genotypic model, P1320 was most signifi...... Under this recessive genotypic model, P1320 was most significant, with an odds ratio of 0.33. More...	Positive
rs760666	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs3213207	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs2619539	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs2619528	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs2619522	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs2005976	DTNBP1			P-value < 0.05 under a recessive model	Single nucleotide polymorphism P1757 had p values <0.05 unde...... Single nucleotide polymorphism P1757 had p values <0.05 under a recessive genotypic model for the rare allele. More...	Positive
rs1018381	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs1011313	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
rs909706	DTNBP1			data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative

Haplotypes reported by this study for BD (count: 8)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2619522 - rs760761 - rs2005976	T-C-G	DTNBP1	P-value = 0.03, Z=-2.07	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive
rs2619522 - rs760761 - rs2005976 - rs2619528	T-C-G-G	DTNBP1	P-value = 0.028, Z=-2.19	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. The 4-5-6-7 haplotype was positive with a significance of p=0.005. More...	Positive
rs2619522 - rs760761 - rs2005976	G-T-A	DTNBP1	P-value = 0.03, Z=1.6	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive
rs2619522 - rs760761 - rs2619528	T-C-G	DTNBP1	P-value = 0.03, Z=-2.11	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive
rs2619522 - rs760761 - rs2005976 - rs2619528	G-T-A-A	DTNBP1	P-value = 0.08, Z=1.73	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. The 4-5-6-7 haplotype was positive with a significance of p=0.005. More...	Negative
rs760761 - rs2005976 - rs2619528	C-G-G	DTNBP1	P-value = 0.03, Z=-2.19	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive
rs2619522 - rs760761 - rs2619528	G-T-A	DTNBP1	P-value = 0.03, Z=1.73	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive
rs760761 - rs2005976 - rs2619528	T-A-A	DTNBP1	P-value = 0.05, Z=1.63	It is one of the most significant 3-marker haplotypes and em...... It is one of the most significant 3-marker haplotypes and empirical p values. More...	Positive

Genes reported by this study for BD (count: 1)