BDgene

SNP Report

Basic Info
Name rs2619522 dbSNP Ensembl
Location chr6:15653418 - 15653418(1)
Variant Alleles A/C
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.242212
Functional Annotation intron_variant; NMD_transcript_variant.
Consequence to Transcript intron_variant(ENST00000338950, ENST00000344537, ENST00000355917, ENST00000506844, ENST00000510395, ENST00000511762, ENST00000513680, ENST00000515875, ENST00000622898, LRG_588t1, LRG_588t2); NMD_transcript_variant(ENST00000506844, ENST00000510395, ENST00000513680, ENST00000515875)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Joo, E. J., 2007 T/G Fisher's exact test, allelic P-value = 0.078 for BPD I, P-va...... Fisher's exact test, allelic P-value = 0.078 for BPD I, P-value = 0.446 for BPD I and II, P-value = 0.826 for BPD I, II and SA; genotypic P-value = 0.014 for BPD I, P-value = 0.031 for BPD I and II, P-value = 0.09 for BPD I, II and SA More... Significant genotypic association with P1763 was observed in...... Significant genotypic association with P1763 was observed in the bipolar I group, significance decreased as the phenotype was broadened to include bipolar II disorder and schizoaffective disorder. More... Positive
Breen, G., 2006 data not shown data not shown did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More... Negative
Gaysina, D.,2009 T/G chi-square test: Between Bipolar Disorder and Control Groups...... chi-square test: Between Bipolar Disorder and Control Groups: genotype: X2=7.21, P-value = 0.027; allele: X2=4.64, P-value = 0.031 More... No significant association was observed in the BD group. No significant association was observed in the BD group. Negative
Pae, C. U., 2007 (a) COCAPHASE P-value > 0.05 COCAPHASE P-value > 0.05 No significant association was observed in single marker ana...... No significant association was observed in single marker analyses More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DTNBP1 dystrobrevin binding protein 1 6p22.3 8(4/3/1)

SNPs in LD with rs2619522 (count: 73) View in gBrowse (chr6:15525222..15657981 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 73)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)