BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Joo, E. J., 2007 PMID: 17433541
Citation	Joo, E. J., K. Y. Lee, et al. (2007). "Dysbindin gene variants are associated with bipolar I disorder in a Korean population." Neurosci Lett 418(3): 272-275.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	163 patients and 350 controls
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Mongloid
Population	Korean
Gender	48 BPD I males; 56 BPD I and II males; 69 BPD I, II and SA males; 174 male controls
Age Group	not mentioned

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All patients with bipolar disorder were randomly recruited from Seoul National University Hospital in Korea. Patients were divided into three groups: bipolar disorder I (112), bipolar disorders I and II (136), and bipolar disorders I and II and schizoaffective disorder (163).
Technique	genotyped with the TaqMan method
Statistical Method	PowerMarker Version 3.25 and SPSS Version 12.0 were used for the genetic data analysis. Allele and genotype associations were evaluated by Fisher's exact test. Haplotype frequencies and the significance of haplotypic associations were determined by haplotype trend regression with 100,000 permutation repeats.
Result Summary	They found significant genotypic associations with P1763 and P1320, but no association with SNP A in the bipolar I group. When they included bipolar II and schizoaffective disorder in the affected phenotype, the significance decreased. A positive association was observed between the SNP A-P1763 haplotype and the bipolar I phenotype. This haplotype association was lost when they either broadened our phenotype or included P1320 in a haplotype. The positive results of the present study lost significance after a Bonferroni correction for multiple testing. These findings are consistent with previous findings that showed a positive association of DTNBP1 with bipolar disorders. Moreover, their results suggest that DTNBP1 may contribute more to bipolar I disorder than bipolar II disorder or schizoaffective disorder. Further comprehensive studies will be required to clarify these association, however, it seems likely that DTNBP1 is a susceptibility gene for bipolar disorder.

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2619538	DTNBP1	A/T		Fisher's exact test, allelic P-value = 0.305 for BPD I, P-value = 0.437 for BPD I and II, P-value = 0.461 for BPD I, II and SA; genotypic P-value = 0.464 for BPD I, P-value = 0.501 for BPD I and II, P-value = 0.548 for BPD I, II and SA	no significant association was detected no significant association was detected	Negative
rs760761	DTNBP1	C/T		Fisher's exact test, allelic P-value = 0.084 for BPD I, P-value = 0.408 for BPD I and II, P-value = 0.76 for BPD I, II and SA; genotypic P-value = 0.022 for BPD I, P-value = 0.058 for BPD I and II, P-value = 0.13 for BPD I, II and SA	Significant genotypic association with P1320 was observed in...... Significant genotypic association with P1320 was observed in the bipolar I group, Significance decreased as the phenotype was broadened to include bipolar II disorder and schizoaffective disorder. More...	Positive
rs2619522	DTNBP1	T/G		Fisher's exact test, allelic P-value = 0.078 for BPD I, P-value = 0.446 for BPD I and II, P-value = 0.826 for BPD I, II and SA; genotypic P-value = 0.014 for BPD I, P-value = 0.031 for BPD I and II, P-value = 0.09 for BPD I, II and SA	Significant genotypic association with P1763 was observed in...... Significant genotypic association with P1763 was observed in the bipolar I group, significance decreased as the phenotype was broadened to include bipolar II disorder and schizoaffective disorder. More...	Positive

Haplotypes reported by this study for BD (count: 3)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2619538 - rs2619522		DTNBP1	P-value = 0.026 for BPD I, P-value = 0.154 for BPD I and II, P-value = 0.311 for BPD I, II and SA	A positive association was observed between the SNP A-P1763 ...... A positive association was observed between the SNP A-P1763 haplotype and the bipolar I phenotype. This haplotypic association was lost when we broadened the phenotype to include bipolar II and schizoaffective disorder. More...	Positive
rs2619522 - rs760761		DTNBP1	P-value = 0.311 for BPD I, P-value = 0.603 for BPD I and II, P-value = 0.838 for BPD I, II and SA	a significant haplotype association was not found in P1763-P...... a significant haplotype association was not found in P1763-P1320 More...	Negative
rs2619538 - rs2619522 - rs760761		DTNBP1	P-value = 0.049 for BPD I, P-value = 0.268 for BPD I and II, P-value = 0.478 for BPD I, II and SA	The haplotypic association was lost when included P1320 in a...... The haplotypic association was lost when included P1320 in a haplotype More...	Negative

Genes reported by this study for BD (count: 1)