SNP Report

Basic Info

Name	rs2619539 dbSNP Ensembl
Location	chr6:15620624 - 15620624(1)
Variant Alleles	C/A/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.473842
Functional Annotation	intron_variant; NMD_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000338950, ENST00000344537, ENST00000355917, ENST00000506844, ENST00000510395, ENST00000511762, ENST00000513680, ENST00000515875, ENST00000622898, LRG_588t1, LRG_588t2); NMD_transcript_variant(ENST00000506844, ENST00000510395, ENST00000513680, ENST00000515875)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Breen, G., 2006		data not shown data not shown	did not show individual genotypic association with bipolar I...... did not show individual genotypic association with bipolar I disorder More...	Negative
Gaysina, D.,2009	C/G	chi-square test: 1.Between Bipolar Disorder and Control Grou...... chi-square test: 1.Between Bipolar Disorder and Control Groups: genotype: X²=1.51, P-value = 0.47; allele: X²=1.2, P-value = 0.273 2.In Bipolar I Disorder (BID) and Bipolar II Disorder (BIID) Groups: allele: X²=0.573, P-value = 0.449 More...	No significant differences was observed between the groups o...... No significant differences was observed between the groups of BD-I and BD-II.No significant association was observed in the BD group. More...	Negative
Raybould, R.,2005	G/C	Single-Marker Analysis: for all BPI, allele P-value = 0.999;...... Single-Marker Analysis: for all BPI, allele P-value = 0.999; for BPI with Psychotic Symptoms in 50% or More of Episodes, allele P-value = 0.415 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DTNBP1	dystrobrevin binding protein 1	6p22.3	8(4/3/1)

SNPs in LD with rs2619539 (count: 5) View in gBrowse (chr6:15533720..15625577 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs4715988	intron_variant; NMD_transcript_variant	0.962[CEU]
rs2743868	intron_variant; NMD_transcript_variant	0.961[CEU]
rs4498340	intron_variant; NMD_transcript_variant	0.961[CEU]
rs9476864	intron_variant; NMD_transcript_variant	1.0[CEU]
rs4236167	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.961[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)