BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	De Luca, V., 2007 PMID: 17532191
Citation	De Luca, V., S. Tharmalingam, et al. (2007). "Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder." Eur Psychiatry 22(5): 282-287.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	312 nuclear families including 1043 subjects; 350 affected with BD and 693 non-affected relatives
SNP/Region/Marker Size	3 variants
Predominant Ethnicity
Population	Canadian
Gender	131 males and 219 females
Age Group	adolescents and adults : subjects ranged in age from 16-67, mean age=35.36 (SD=10.37) years

Detail Info

Haplotypes reported by this study for BD (count: 7)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-2-5	CRHR2	FBAT P-value = 0.132, Z=-1.508	yielded non-significant results yielded non-significant results	Negative
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-2-3	CRHR2	FBAT P-value = 0.004, Z=-2.853	the haplotype 5-2-3 was protective the haplotype 5-2-3 was protective	Positive
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-7-8	CRHR2	FBAT P-value = 0.01, Z=2.57	the haplotype 5-7-8 was associated with the disease the haplotype 5-7-8 was associated with the disease	Positive
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-3-3	CRHR2	FBAT P-value = 0.84, Z=0.202	yielded non-significant results yielded non-significant results	Negative
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	3-3-7	CRHR2	FBAT P-value = 0.655, Z=0.447	yielded non-significant results yielded non-significant results	Negative
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-3-6	CRHR2	FBAT P-value = 0.879, Z=0.152	yielded non-significant results yielded non-significant results	Negative
CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n	5-7-7	CRHR2	FBAT P-value = 0.781, Z=0.279	yielded non-significant results yielded non-significant results	Negative

Other variants reported by this study for BD (count: 3)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
CRHR2 intron4 (CA)n	CRHR2	microsatellite			FBAT P-value = 0.568, Z=-0.571 for allele 3; FBAT P-value = 0.251, Z=1.147 for allele 4; FBAT P-value = 0.971, Z=-0.036 for allele 5 under additive model	FBAT global p-value from parents to affected proband yielded...... FBAT global p-value from parents to affected proband yielded non-significant results More...	Negative
CRHR2 intron10 (GT)n	CRHR2	microsatellite			FBAT P-value = 0.71, Z=-0.371 for allele 2; FBAT P-value = 0.059, Z=-1.889 for allele 3; FBAT P-value = 0.564, Z=-0.577 for allele 5; FBAT P-value = 0.564, Z=0.577 for allele 6; FBAT P-value = 0.983, Z=0.021 for allele 7; FBAT P-value = 0.195, Z=1.296 for allele 8; FBAT P-value = 1, Z=0 for allele 9 under additive model	FBAT global p-value from parents to affected proband yielded...... FBAT global p-value from parents to affected proband yielded non-significant results More...	Negative
CRHR2 intron10 (GAT)n	CRHR2	microsatellite			FBAT P-value = 0.008, Z=-2.654 for allele 2; FBAT P-value = 1, Z=0 for allele 3; FBAT P-value = 0.027, Z=2.215 for allele 7 under additive model	FBAT global p-value from parents to affected proband yielded...... FBAT global p-value from parents to affected proband yielded non significant results, however the GAT marker showed a slight trend (p=0.056); allele 7 is conferring risk for bipolar disorder and allele 2 is protective More...	Positive

Genes reported by this study for BD (count: 1)