BDgene

Study Report

Basic Info
Reference
Citation Crisafulli, C., D. S. Shim, et al. (2012). "Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder." Psychiatry Res.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 145 MDD patients,132 BD patients and 170 healthy controls
SNP/Region/Marker Size 14 SNPs
Predominant Ethnicity Mongloid
Population Korean
Gender 52% males for MDD patients,66% males for BD patients and 62% males for controls
Age Group Adults : Mean age(SD)(year):41.37(14.07) for MDD patients,36.35(11.60) for BD patients and 38.83(12.80) for controls

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 13)

Genes reported by this study for BD (count: 3)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs130021 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs16935888 CREM Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs129974 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs130005 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs3025702 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs4934735 CREM Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs2239316 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs2239317 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs9392 CREBBP Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs6481941 CREM Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs6740584 CREB1 Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs12775799 CREM Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative
MDD rs1148247 CREM Association analysis:genotype P-value = >0.05;allele P-value > 0.05 No significant association was observed in MDD. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD CREM We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. Negative
MDD CREB1 We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. Negative
MDD CREBBP We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. Negative