Study Report
Basic Info
| Reference |
Hong, C. J., 2004 PMID: 14729237
|
| Citation |
Hong, C. J., I. C. Lai, et al. (2004). "Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder." Neurosci Lett 355(1-2): 69-72.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
This study included 77 psychiatric inpatients with the primary diagnosis of BPD and 135 normal control subjects |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Gender |
BPD patients (39 male and 38 female), control population (70 male and 65 female) |
| Age Group |
adults
:
BPD patients mean age=37.7 (SD=14.6) years; healthy controls: mean age=35.9 (SD=8.4) years,
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
Hallucinations or delusions were noted in 31 of the 77 BPD patients. |
| Technique |
PCR and genotyping |
| Statistical Method |
Categorical data were analyzed using the Chi-square test. Continuous variables were analyzed using Student's t-test or one-way analysis of variance. In all of the tests, the criterion for significance was set at P < 0:05. |
| Result Summary |
The distribution of -2 bp genotypes showed a moderately significant difference between the BPD patients and controls (P=0.044). Three BPD patients carried more than two alleles of the -2 bp deletion genotype, while this genotype was not found in the control group. The -2 bp polymorphism was not associated with age of onset or psychotic features in BPD patients. The results of this study suggest that the -2 bp polymorphism or a nearby polymorphism may play a role in the pathogenesis of BPD. Determination of the functional impact of the -2 bp variant in the nervous system and, in particular, the effect of harboring more than two alleles of the -2 bp deletion needs further exploration. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| -2 bp deletion polymorphism |
CHRNA7 |
insertion/deletion |
|
|
Genotypic P-value = 0.0044
|
The distribution of the -2 bp genotypes showed a marginally ......
The distribution of the -2 bp genotypes showed a marginally significant difference between BPD patients and controls
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| CHRNA7 |
A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene. The distri......
A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene. The distribution of -2 bp genotypes showed a moderately significant difference between the BPD patients and controls.
More...
|
Positive
|
