BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Choi, K. Y., 2010 PMID: 20396435
Citation	Choi, K. Y., H. K. Yoon, et al. (2010). "Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population." Psychiatry Investig 7(1): 60-7.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	103 bipolar disorder patients and 86 control subjects
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Mongloid
Population	Korean
Gender	53.5% female for all patients, 40.7% female for controls.
Age Group	adult : mean(SD)=33.7(10.6) for all patients, mean(SD)=31.2(9.7) for controls.

Detail Info

Other variants reported by this study for BD (count: 3)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
5-HT2A promoter 1438A/G	HTR2A	point mutation	A/G		Genotype: X²(df=2)=3.01, P-value = 0.223, allele: X²(df=1)=0.75, P-value = 0.388 between all patients and controls. Genotype: X²=7.50, P-value = 0.024; allele: X²=5.92, P-value = 0.015 between the psychotic mania group and the non-psychotic manic group.	There were no significant differences in the genotype distri...... There were no significant differences in the genotype distributions or allelic frequencies in the three serotonergic polymorphisms between patients with bipolar disorder and normal controls. There were significant differences in genotype distributions and allele frequencies of the 5-HT2A -1438A/G polymorphism between the psychotic mania group and the non-psychotic mania group. More...	Positive
TPH1 promoter 218A/C	TPH1	point mutation	A/C		Genotype: X²(df=2)=0.187, P-value = 0.911, allele: X²(df=1)=0.203, P-value = 0.652 between all patients and controls. Genotype: X²=3.01, P-value = 0.222; allele: X²=3.16, P-value = 0.076 between the psychotic mania group and the non-psychotic manic group.	There were no significant differences in the genotype distri...... There were no significant differences in the genotype distributions or allelic frequencies in the three serotonergic polymorphisms between patients with bipolar disorder and normal controls. We did not find significant differences in the genotype distributions or allelic frequencies in the TPH1 218 A/C and TPH2 703G/T polymorphisms between the psychotic mania group and non-psychotic mania group. More...	Negative
TPH2 promoter 703G/T	TPH2	point mutation	G/T		Genotype: X²(df=2)=1.48, P-value = 0.477, allele: X²(df=1)=0.782, P-value = 0.376 between all patients and controls. Genotype: X²=0.207, P-value = 0.902; allele: X²=0.065, P-value = 0.798 between the psychotic mania group and the non-psychotic manic group.	There were no significant differences in the genotype distri...... There were no significant differences in the genotype distributions or allelic frequencies in the three serotonergic polymorphisms between patients with bipolar disorder and normal controls. We did not find significant differences in the genotype distributions or allelic frequencies in the TPH1 218 A/C and TPH2 703G/T polymorphisms between the psychotic mania group and non-psychotic mania group. More...	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
TPH2	There was no association of variant in this gene with bipolar disorder. There was no association of variant in this gene with bipolar disorder.	Negative
TPH1	There was no association of variant in this gene with bipolar disorder. There was no association of variant in this gene with bipolar disorder.	Negative
HTR2A	There was a trend towards association between 5-HT2A -1438A/G polymorphism and psychotic symptom in ...... There was a trend towards association between 5-HT2A -1438A/G polymorphism and psychotic symptom in bipolar disorder. More...	Positive