BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	TPH1 promoter 218A/C
Type	point mutation
Location	promoter
Length of Repeat Unit	1bp
Related Gene	TPH1
No. of Study	1 (Positive: 0; Negative 1; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Choi, K. Y., 2010	A/C		Genotype: X²(df=2)=0.187, P-value = 0.911, allele: X²(df=1)=0.203, P-value = 0.652 between all patients and controls. Genotype: X²=3.01, P-value = 0.222; allele: X²=3.16, P-value = 0.076 between the psychotic mania group and the non-psychotic manic group.	There were no significant differences in the genotype distri..... More There were no significant differences in the genotype distributions or allelic frequencies in the three serotonergic polymorphisms between patients with bipolar disorder and normal controls. We did not find significant differences in the genotype distributions or allelic frequencies in the TPH1 218 A/C and TPH2 703G/T polymorphisms between the psychotic mania group and non-psychotic mania group. Less	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)