Study Report
Basic Info
| Reference |
Bellivier, F., 1998 (a) PMID: 9435758
|
| Citation |
Bellivier, F., M. Leboyer, et al. (1998). "Association between the tryptophan hydroxylase gene and manic-depressive illness." Arch Gen Psychiatry 55(1): 33-37.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
152 patients with bipolar and 94 healthy volunteers |
| SNP/Region/Marker Size |
1 variant |
| Predominant Ethnicity |
Caucasian |
| Population |
French |
| Gender |
84 women and 68 men with bipolar, 37 women and 57 men controls |
| Age Group |
adults
:
mean age at interview=46.9 (sd=15.3) years of patients, mean age at interview=43.7 (sd=5.6) years of controls
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Detail Info
| Sample Diagnosis |
DSM-III-R, Research Diagnostic Criteria |
| Sample Status |
Patients with bipolar disorder (103 patients with bipolar I disorder and 49 patients with bipolar II disorder) were recruited from consecutive admissions to the psychiatric unit. |
| Technique |
PCR amplification and genotyping |
| Statistical Method |
Allelic and genotypic distributions between patients and controls were compared using the x2 test. Odds ratios and 95% confidence intervals were calculated using the Woolfos method. The Armitage linearity tendency test38 was used to identify any dose effect of a susceptibility allele. Differences were considered statistically significant at P=.05. |
| Result Summary |
There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior. This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| TPH1 A218C |
TPH1 |
point mutation |
A/C |
|
(a) vs (b) for genotypic distribution, X2=12.23, df=2, P-value=0.002; (a) vs (b) for allelic distribution, X2=12, df=1, P-value=0.001; (c) vs (d) for allelic distribution, X2=1.46, df=1, P-value=0.22; (e) vs (f) for allelic distribution, X2=0.03, df=1, P-value=0.86
|
There was an association between TPH genotype and manicdepre......
There was an association between TPH genotype and manicdepressive illness (x2=12.23, df=2; P,.02). The allelic distributions for patients and controls were significantly different (x2=12.00, df=1; P=.001).
More...
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Positive
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| TPH1 |
This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. ......
This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls.
More...
|
Positive
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