Study Report
Basic Info
| Reference |
Rietschel, M.,2000 PMID: 10898906
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| Citation |
Rietschel, M., A. Schorr, et al. (2000). "Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls." Am J Med Genet 96(3): 310-311.
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| Disease Type |
Bipolar I Disorder |
| Study Design |
family-based |
| Study Type |
Candidate-gene association study |
| Sample Size |
95 bipolar I patients and their parents |
| SNP/Region/Marker Size |
1 variant |
| Predominant Ethnicity |
Caucasian |
| Population |
German |
| Gender |
54 males, 41 females |
| Age Group |
Adults
:
Mean age at interview of patients was 33.8 years (SD 7.4), and mean age at first episode was 22.4 years (SD 5.5).
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Detail Info
| Sample Diagnosis |
DSM |
| Technique |
genotyping |
| Statistical Method |
transmission disequilibrium test' (TDT) |
| Result Summary |
Our sample yielded a power >90% to detect the originally reported effect. Neither allele 218A nor allele 218C were preferentially transmitted from heterozygous parents to bipolar offspring. Our results, therefore, do not support the hypothesis that the TPH gene is involved in the etiology of bipolar disorder. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| TPH1 A218C |
TPH1 |
point mutation |
A218C |
|
Association analysis: TDT=0.04; P-value = 0.92
|
No significant association was observed.
No significant association was observed.
|
Negative
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| TPH1 |
Our results, therefore, do not support the hypothesis that the TPH gene is involved in the etiology ......
Our results, therefore, do not support the hypothesis that the TPH gene is involved in the etiology of bipolar disorder.
More...
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Negative
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