BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Abou Jamra, R., 2004 PMID: 15048653
Citation	Abou Jamra, R., J. Schumacher, et al. (2004). "Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder." Am J Med Genet B Neuropsychiatr Genet 126B(1): 79-81.
Disease Type	Bipolar I Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	120 parent-offspring triads
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Caucasian
Population	German

Detail Info

Other variants reported by this study for BD (count: 3)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
ADRA2A -1291C>G	ADRA2A	point mutation	C>G		X²= 1.64, P-value = 0.20 for -1291C; X²= 1.64, P-value = 0.20 for -1291G	We observed no significant differences in transmissions for ...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative
ADRA2C 5'UTR (GT)n	ADRA2C	microsatellite	STR		X²= 3.00, P-value = 0.08 for 175 bp; X²= 3.27, P-value = 0.07 for 181 bp; X²= 1.17, P-value = 0.28 for 183 bp; X²= 0.15, P-value = 0.70 for 185 bp; X²= 0.07, P-value = 0.80 for 187 bp; X²= 0.00, P-value = 1.00 for 189 bp; X²= 2.00, P-value = 0.16 for 191 bp	We observed no significant differences in transmissions for ...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative
ADRA1A 492C>T	ADRA1A	point mutation	C>T		X²= 0.00, P-value = 1.00 for 492C; X²= 0.00, P-value = 1.00 for 492T	We observed no significant differences in transmissions for ...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
ADRA2A	We observed no significant differences in transmissions for any of the genetic variants in the three...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative
ADRA2C	We observed no significant differences in transmissions for any of the genetic variants in the three...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative
ADRA1A	We observed no significant differences in transmissions for any of the genetic variants in the three...... We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. More...	Negative