SNP Report

Basic Info

Name	rs1048101 dbSNP Ensembl
Location	chr8:26770511 - 26770511(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.351837
Functional Annotation	intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000276393, ENST00000354550, ENST00000380573, ENST00000380582, ENST00000380586, ENST00000519229) SIFT Annotation: tolerated(ENST00000276393, ENST00000354550, ENST00000380573, ENST00000380582, ENST00000380586, ENST00000519229)
Consequence to Transcript	intron_variant(ENST00000519096, ENST00000521711); missense_variant(ENST00000276393, ENST00000354550, ENST00000380573, ENST00000380582, ENST00000380586, ENST00000519229); NMD_transcript_variant(ENST00000519096, ENST00000521711); non_coding_transcript_exon_variant(ENST00000518621); non_coding_transcript_variant(ENST00000518621); upstream_gene_variant(ENST00000486251)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Shi, J., 2008 (b)	A/G	G	Allelic association of neurotransmission systems genes with ...... Allelic association of neurotransmission systems genes with bipolar disorder: TDT P-value = 0.0306, Gene-wide P-value = 0.1888 (P values were based on permutation for all SNPs in each gene). More...		Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ADRA1A	adrenoceptor alpha 1A	8p21.2	2(0/2/0)

SNPs in LD with rs1048101 (count: 10) View in gBrowse (chr8:26755891..26812200 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs3802241	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant	0.885[CEU]; 0.954[TSI]
rs6998591	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.961[CEU]; 0.932[TSI]
rs2055195	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.921[CEU]; 0.909[TSI]
rs3739215	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.922[CEU]; 0.932[TSI]
rs2055197	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.878[CEU]
rs937351	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]
rs13277287	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs4236678	intron_variant; NMD_transcript_variant	0.922[CEU]; 0.954[TSI]
rs6557946	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.96[CEU]; 1.0[TSI]
rs7842829	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)