BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Prata, D. P., 2006 PMID: 17106420
Citation	Prata, D. P., G. Breen, et al. (2006). "Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes." Psychiatr Genet 16(6): 229-230.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	213 cases and 197 controls
SNP/Region/Marker Size	15 SNPs
Predominant Ethnicity	Caucasian
Population	Scottish

Detail Info

SNPs reported by this study for BD (count: 14)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4680	COMT			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs558934	ADRBK2			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs5761116	ADRBK2			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs576895	ADRBK2			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs737865	COMT TXNRD2			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs951436	RGS4			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs951439	RGS4			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs165599	ARVCF COMT			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs1808320	PRODH			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs2661319	RGS4			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs372055	PRODH DGCR6			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs383964	PRODH DGCR6			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs385440	PRODH DGCR6			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive
rs450046	PRODH DGCR6			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Positive

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
RGS4 SNP1	RGS4	point mutation			no P-value	A chi-square analysis showed no genotype-wise or allele-wise...... A chi-square analysis showed no genotype-wise or allele-wise association for any individual SNP. More...	Negative

Genes reported by this study for BD (count: 4)

Gene	Statistical Values/Author Comments	Result Category
ADRBK2	Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipo...... Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. More...	Negative
COMT	Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipo...... Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. More...	Negative
RGS4	Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipo...... Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. More...	Negative
PRODH	Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipo...... Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. More...	Negative