BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Region Report

Basic Info

Region Name	18p11
Chromosome Position	chr18:0-18500000
No. of Studies (Positive/Negative/Trend)	6(1/2/3)

Region related studies (count: 6)

Reference	Markers	Statistical Values	Author Comments	Result Category
Nwulia, E. A.,2007	D18S843	Non-parametric multipoint linkage analysis: NPL = 1.99, P-va...... Non-parametric multipoint linkage analysis: NPL = 1.99, P-value = 0.02 More...	There is a trend for Significant linkage. There is a trend for Significant linkage.	Trend
Bennett, P.,2002	D18S452	Linkage analysis: LOD = 1.24, Multipoint MLS(narrow model) =...... Linkage analysis: LOD = 1.24, Multipoint MLS(narrow model) = 1.54 More...	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Service, S.,2006	rs1539935	Two point parametric linkage analysis: LOD = 1.2365 Two point parametric linkage analysis: LOD = 1.2365	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
Evans, L. M.,2008		Nonparametric Multipoint Regression Linkage Analyses: Associ...... Nonparametric Multipoint Regression Linkage Analyses: Associated P-values From MERLIN is 0.0002, LOD score is 2.71. More...	There is a trend for Significant linkage. There is a trend for Significant linkage.	Trend
Mulle, J. G., 2007		For marker rs1893157: Allelic TDT X² = 9.031, P...... For marker rs1893157: Allelic TDT X² = 9.031, P-value = 0.0027. Paternal stratified TDT P-value = 0.00009, maternal stratified TDT P-value = 0.88, total stratified TDT P-value = 0.002. Paternal TAT P-value = 0.0008, maternal TAT P-value = 0.75, total TAT P-value = 0.005. LDR X²(df = 1) = 11.82, P-value = 0.0006; For marker rs789024: Paternal stratified TDT P-value = 0.00007, maternal stratified TDT P-value = 0.78, total stratified TDT P-value = 0.003; Paternal TAT P-value = 0.01, maternal TAT P-value = 0.24, total TAT P-value = 0.35. LDR X²(df = 1) = 14.41, P-value = 0.0001 More...	when parent-of-origin of transmitted SNPs was taken into acc...... when parent-of-origin of transmitted SNPs was taken into account, these loci confer substantial risk for bipolar disorder. More...	Positive
Georgi, B., 2014	D18S453	expLOD=2.76 expLOD=2.76	Within the full set of 49 nuclear families the highest linka...... Within the full set of 49 nuclear families the highest linkage we observed was on 18p11 (expLOD 2.76 at D18S453, BPI phenotype). More...	Trend

Region related genes (count: 12)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	18p11.31	1(1/0/0)
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	18p11.2	1(1/0/0)
MYL12B	myosin, light chain 12B, regulatory	18p11.31	1(1/0/0)
NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	18p11.21	3(2/1/0)
CIDEA	cell death-inducing DFFA-like effector a	18p11.21	1(0/0/1)
MC5R	melanocortin 5 receptor	18p11.2	1(0/1/0)
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	18p11	3(1/2/0)
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	18p11.22	6(5/1/0)
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	18p11.2	4(2/2/0)
CHMP1B	charged multivesicular body protein 1B	18p11.21	2(0/2/0)
MPPE1	metallophosphoesterase 1	18p11.21	2(2/0/0)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	2(0/2/0)

View in gBrowse

Region: chr18:0..18500000 View in gBrowse