BDgene

SNP Report

Basic Info
Name rs12576775 dbSNP Ensembl
Location chr11:79366149 - 79366149(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.104433
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000278550, ENST00000528688, ENST00000531583); non_coding_transcript_variant(ENST00000528688, ENST00000531583)
No. of Studies 4 (Positive: 4; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Muhleisen, T. W., 2014 G/A G MooDS: P-value=0.0294, OR=1.13; PGC: P-value=2.66E-8, OR=1.1...... MooDS: P-value=0.0294, OR=1.13; PGC: P-value=2.66E-8, OR=1.18; MooDS-PGC: P-value=3.27E-9, adjusted P-value=4.46E-9, OR=1.17 More... Eighteen GWAS SNPs showing genome-wide evidence for associat...... Eighteen GWAS SNPs showing genome-wide evidence for association with BD in the combined MooDS and PGC samples. More... Positive
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 G/A Association analysis:P-value = 0.000000044 in BPD. Association analysis:P-value = 0.000000044 in BPD. Significant association was observed in BPD. Significant association was observed in BPD. Positive
Green, E. K.,2012 A/G BD ImmunoChip:P-value = 0.047,OR = 0.887;ImmunoChip, PGC-BD ...... BD ImmunoChip:P-value = 0.047,OR = 0.887;ImmunoChip, PGC-BD combined data:P-balue = 0.0000000062,OR = 0.881 More... The SNP showed a significant association with BD. The SNP showed a significant association with BD. Positive
Sklar, P.,2011 A/G Primary GWAS P-value(GC)=0.000000209, OR=0.85; replication P...... Primary GWAS P-value(GC)=0.000000209, OR=0.85; replication P-value(1-sided)=0.00759, OR=0.92; Combined GWAS and replication P-value(GC)=0.000000044, OR=0.88 More... Significant association was found in combined analysis . Significant association was found in combined analysis . Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TENM4 teneurin transmembrane protein 4 11q13 6(4/2/0)

SNPs in LD with rs12576775 (count: 5) View in gBrowse (chr11:79346052..79367625 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 5)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)