BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Li, Y.,2010 PMID: 20414142
Citation	Li, Y., Q. Zhao, et al. (2010). "Association study between RGS4 and bipolar disorder in the Chinese Han population." Psychiatr Genet 20(3): 130-132.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	Four hundred and eighty-four patients (82% are bipolar disorder 1 patients) and 288 controls
SNP/Region/Marker Size	5 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	273 male and 211 female in BD patients;159 male and 129 female in controls
Age Group	average age 39.3 years for BD patients

Detail Info

SNPs reported by this study for BD (count: 4)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs951439	RGS4	A/G		Allele association: P-value = 0.11, OR(95%CI)=0.838551(0.676984-1.038675)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2842030	RGS4	G/T		Allele association: P-value = 0.17, OR(95%CI)=0.860962(0.695003-1.066551)	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs951436	RGS4	G/T		Allele association: P-value = 0.0078, OR(95%CI)=1.334761(1.078658-1.651668)	Significant association was found in BD. Significant association was found in BD.	Positive
rs266131	RGS4	A/G		Allele association: P-value = 0.31, OR(95%CI)=0.896552(0.726145-1.106949)	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 5)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs951436 - rs951439 - rs266131 - rs2842030	G-G-A-T	RGS4	Haplotype analysis:X<sup>2</sup>=2.143, Fisher's P-value = 0.143261, Pearson's P-value = 0.143186, OR(95%CI)=1.746(0.821-3.714)	No significant association was found . No significant association was found .	Negative
rs951436 - rs951439 - rs266131 - rs2842030	G-G-G-T	RGS4	Haplotype analysis:X<sup>2</sup>=2.249, Fisher's P-value = 0.133748, Pearson's P-value = 0.133674, OR(95%CI)=1.189(0.948-1.491)	No significant association was found . No significant association was found .	Negative
rs951436 - rs951439 - rs266131 - rs2842030	G-G-A-G	RGS4	Haplotype analysis:X<sup>2</sup>=2.598, Fisher's P-value = 0.107075, Pearson's P-value = 0.107008, OR(95%CI)=1.66(0.891-3.094)	No significant association was found . No significant association was found .	Negative
rs951436 - rs951439 - rs266131 - rs2842030	T-A-A-G	RGS4	Haplotype analysis:X<sup>2</sup>=5.367, Fisher's P-value = 0.020558, Pearson's P-value = 0.020539, OR(95%CI)=0.764(0.608-0.960)	Significant association was found in BD-II. Significant association was found in BD-II.	Positive
rs951436 - rs951439 - rs266131 - rs2842030	T-G-A-T	RGS4	Haplotype analysis:X<sup>2</sup>=0.651, Fisher's P-value = 0.419848, Pearson's P-value = 0.419814, OR(95%CI)=0.799(0.462-1.380)	No significant association was found . No significant association was found .	Negative

Genes reported by this study for BD (count: 1)