SNP Report

Basic Info

Name	rs2433322 dbSNP Ensembl
Location	chr4:94458590 - 94458590(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.271765
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000359265, ENST00000504489, ENST00000512274); intron_variant(ENST00000317968, ENST00000318007, ENST00000380180, ENST00000437932, ENST00000503974, ENST00000508216, ENST00000509333, ENST00000511767, ENST00000514743, ENST00000514830, ENST00000542407, ENST00000615540, ENST00000627587); NMD_transcript_variant(ENST00000627587); non_coding_transcript_variant(ENST00000509333, ENST00000511767, ENST00000514830)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Squassina, A.,2008	A/G		Allelic P-value = 0.288; OR=1.1; genotypic P-value = 0.068 Allelic P-value = 0.288; OR=1.1; genotypic P-value = 0.068	In single-marker analysis, no association was found for any ...... In single-marker analysis, no association was found for any of the SNPs tested. More...	Negative
Zhao, T.,2009	A/G		Allelic association: among patients and controls, P-value = ...... Allelic association: among patients and controls, P-value = 0.002, OR (95% CI)=1.51(1.17-1.97); among patients with bipolar disorder I and controls, P-value = 0.002, OR (95% CI)=1.52(1.16-1.20). Genotypic Association: among patients and controls, P-value = 0.01; among patients with bipolar disorder I and controls, P-value = 0.013 More...	Significant association was observed in both BP and BPI. Significant association was observed in both BP and BPI.	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
PDLIM5	PDZ and LIM domain 5	4q22	5(4/1/0)

SNPs in LD with rs2433322 (count: 8) View in gBrowse (chr4:94439195..94489213 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2510763	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs774982	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.877[CEU]
rs2433327	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.88[CEU]
rs7697295		0.847[CEU]; 0.814[TSI]
rs9990976	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.811[CEU]
rs17378777	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 0.977[TSI]; 1.0[CHB]; 0.93[CHD]; 1.0[JPT]
rs6812165		1.0[CEU]; 0.924[CHB]; 0.924[JPT]
rs2510762	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)