BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Li, X.,2009 PMID: 19429185
Citation	Li, X., J. Zhang, et al. (2009). Association study on the NAPG gene and bipolar disorder in the Chinese Han population. Neurosci Lett 457(3): 159-162.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	465 unrelated controls and 499 unrelated bipolar patients(414 BD-I)
SNP/Region/Marker Size	5 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	male/female: 282/217 in BD patients and 267/198 in controls
Age Group	mean age(year):BD patients:37.7(SD=11.4),age of onset:26.8(SD=10.6); healthy controls:37.2(SD=8.6)

Detail Info

Sample Diagnosis	DSM
Sample Status	All the subjects were from Anhui and were of Han origin. Among the 499 bipolar patients, 414 (83%)were diagnosed as type I bipolar. DSM-IV was used as the diagnostic criterion. Two independent psychiatrists made a final diagnosis on the basis of interviewdata and hospital case notes. All subjects gave informed consent for the genetic analysis, whichwas reviewed and approved by the ethical committee of the Human Genetics Center in Shanghai. The normal controls recruited were not assessed for psychiatric symptoms and were reported to be in good health.
Technique	genotyping
Statistical Method	Chi square test
Result Summary	RESULTS: Rs617040 was excluded from further analysis because of deviation from Hardy-Weinberg equilibrium. Rs473938 and rs2290279 showed significant association in both allele and genotype frequencies (rs473938: allele p=0.0028 after 100,000 permutations, genotype p=0.0018; rs2290279: allele p=0.0042 after 100,000 permutations, genotype p=0.0028). Several combinations of haplotype were found to be associated with bipolar disorder. Haplotype T-A-T of rs473938-rs2290279-rs495484 was defined by confidence intervals algorithm and had a p value of 0.0038 after 100,000 permutations. CONCLUSIONS: Our study supports NAPG as a candidate for susceptibility to bipolar disorder.

SNPs reported by this study for BD (count: 4)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2290279	NAPG	G/A	G	1.BD patients and control: Allele distribution: Permutated P-value = 0.0042, Genotype distribution: P-value = 0.0028; 2.BD-I patients and control: Allele distribution: Permutated P-value = 0.003, Genotype distribution: P-value = 0.0008	Significant association was observed both in the BD group an...... Significant association was observed both in the BD group and the BD-I group. More...	Positive
rs495484	NAPG	A/T	A	1.BD patients and control: Allele distribution: Permutated P-value = 0.4761, Genotype distribution: P-value = 0.1451; 2.BD-I patients and control: Allele distribution: Permutated P-value = 0.3773, Genotype distribution: P-value = 0.0456	No significant association was observed in BD group or BD-I ...... No significant association was observed in BD group or BD-I group. More...	Negative
rs473938	NAPG	A/T	A	1.BD patients and control: Allele distribution: Permutated P-value = 0.0028, Genotype distribution: P-value = 0.0018; 2.BD-I patients and control: Allele distribution: Permutated P-value = 0.0037, Genotype distribution: P-value = 0.0023	Significant association was observed both in the BD group an...... Significant association was observed both in the BD group and the BD-I group. More...	Positive
rs510110	NAPG	A/C	C	1.BD patients and control: Allele distribution: Permutated P-value = 0.8115, Genotype distribution: P-value = 0.1981; 2.BD-I patients and control: Allele distribution: Permutated P-value = 0.6151, Genotype distribution: P-value = 0.0585	No significant association was observed in BD group or BD-I ...... No significant association was observed in BD group or BD-I group. More...	Negative

Haplotypes reported by this study for BD (count: 10)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2290279 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.008892, Most associated individual haplotype:A-A, Individual P-value = 0.004488	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs2290279		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.0004076, Most associated individual haplotype:T-A, Individual P-value = 0.0001676	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs2290279 - rs495484		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.001455, Most associated individual haplotype:T-A-T, Individual P-value = 0.0004148	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs2290279 - rs495484 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.002355, Most associated individual haplotype:T-A-T-A, Individual P-value = 0.0003893	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs2290279 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.00164, Most associated individual haplotype:T-A-A, Individual P-value = 0.0002869	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs495484		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.006632, Most associated individual haplotype:T-T, Individual P-value = 0.001235	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs495484 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.007463, Most associated individual haplotype:T-T-A, Individual P-value = 0.001339	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs473938 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.004815, Most associated individual haplotype:T-A, Individual P-value = 0.00103	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs2290279 - rs495484		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.003584, Most associated individual haplotype:A-T, Individual P-value = 0.00254	We detected significant associations in BP group. We detected significant associations in BP group.	Positive
rs2290279 - rs495484 - rs510110		NAPG	haplotype frequencies in bipolar patients and controls:Global P-value = 0.013, Most associated individual haplotype:A-T-A, Individual P-value = 0.004929	We detected significant associations in BP group. We detected significant associations in BP group.	Positive

Genes reported by this study for BD (count: 1)