BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Weller, A. E., 2006 PMID: 16395123
Citation	Weller, A. E., J. P. Dahl, et al. (2006). "Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder." Psychiatr Genet 16(1): 3-8.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	460 bipolar patients and 191 controls
Predominant Ethnicity	Caucasian
Population	NIMH collections
Gender	38% male

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All individuals (38% male) were of European ancestry and had a diagnosis of type I BPD as defined by DSM-IV criteria. The key criterion for admission of a family to the study was a working diagnosis of type I BPD in two or more siblings.
Technique	genotyping was performed using Applied Biosystems Assays on Demand genotyping reagents
Statistical Method	Genotypic and allelic frequencies were compared between case and control populations using chi squared contingency analysis. Statistically significant deviations were determined using a two-tailed type I error rate of 5%.
Result Summary	The genotype results indicate that three of the single-nucleotide polymorphisms in the NAPG gene, rs2290279 (P=0.027), rs495484 (P=0.044) and rs510110 (P=0.046), show a nominal, statistically significant association with bipolar disorder at the genotype frequency level. The results of this study suggest that polymorphisms in the human NAPG gene may represent risk factors for the development of bipolar disorder, but before such a role can be established, the results of this study must be confirmed in additional populations of bipolar disorder patients and controls.

SNPs reported by this study for BD (count: 5)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs510110	NAPG	A/C		genotypic P-value = 0.046, allelic P-value = 0.355	showed a nominal, statistically significant association with...... showed a nominal, statistically significant association with BPD at the genotype frequency level but not at the allele frequency level More...	Positive
rs495484	NAPG	A/T		genotypic P-value = 0.044, allelic P-value = 0.396	showed a nominal, statistically significant association with...... showed a nominal, statistically significant association with BPD at the genotype frequency level but not at the allele frequency level More...	Positive
rs473938	NAPG	A/T		genotypic P-value = 0.146, allelic P-value = 0.224		Negative
rs2290279	NAPG	G/A		genotypic P-value = 0.027, allelic P-value = 0.157	showed a nominal, statistically significant association with...... showed a nominal, statistically significant association with BPD at the genotype frequency level but not at the allele frequency level More...	Positive
rs617040	NAPG	A/C		genotypic P-value = 0.188, allelic P-value = 0.47		Negative

Genes reported by this study for BD (count: 1)