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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Lohoff, F. W., 2010 PMID: 19859903 |
|---|---|
| Citation | Lohoff, F. W., T. N. Ferraro, et al. (2010). "Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder." Am J Med Genet B Neuropsychiatr Genet 153B(3): 830-836. |
| Disease Type | Bipolar I Disorder |
| Study Design | case-control |
| Study Type | Candidate-gene association study |
| Sample Size | 570 patients and 725 controls |
| SNP/Region/Marker Size | 4 SNPs |
| Predominant Ethnicity | |
| Gender | 38% males and 62% females for patients, 50% males and 50% females for controls. |
| Age Group | adult : average age at recruitment was 41.6 years for patients, average age at 51.8 years for controls. |
Detail Info
| Sample Diagnosis | DSM-IV |
|---|---|
| Sample Status | Background, inclusion, and exclusion criteria as well as detailed methodology for the NIMH Genetics Initiative are described elsewhere [Dick et al., 2003]. |
| Technique | SNP genotyping was performed using Applied Biosystems, Inc. (ABI) (Foster City, CA) 'Assayson-demand' as per manufacturer protocol. |
| Statistical Method | Genotypes and allele frequencies were compared between groups using Chi square contingency analysis. Linkage disequilibrium (LD) between markers was calculated and estimated haplotype frequencies were compared between groups. |
| Result Summary | Single marker analysis revealed an association of rs3974590 with BPD (P=0.009; permutation corrected P=0.046). Haplotype analysis did not show any significant association with disease after permutation correction. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs871044 | MPPE1 | G/A | genotype test P-value = 0.498, allele test P-value = 0.704 | Negative | ||
| rs602201 | GNAL MPPE1 | T/A | genotype test P-value = 0.946, allele test P-value = 0.739 | Negative | ||
| rs593713 | GNAL MPPE1 | G/A | genotype test P-value = 0.122, allele test P-value = 0.051 | trend towards association trend towards association | Negative | |
| rs3974590 | MPPE1 | G/A | genotype test P-value = 0.022, allele test P-value = 0.009, P-value = 0.046 after permutation correction | statistically significant association statistically significant association | Positive |
| Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|
| rs3974590 - rs593713 | GA | MPPE1 | Chi square=6.589, P-value = 0.01, permutation P-value = 0.0495 | association between the GA haplotype and BPD. association between the GA haplotype and BPD. | Positive |
| rs3974590 - rs593713 | GG | MPPE1 | Chi square=0.054, P-value = 0.816, permutation P-value = 1 | Negative | |
| rs3974590 - rs593713 | AG | MPPE1 | Chi square=3.607, P-value = 0.058, permutation P-value = 0.259 | Negative | |
| rs871044 - rs3974590 - rs593713 - rs602201 | GGAT | MPPE1 | Chi square=0.79, P-value = 0.374, permutation P-value = 0.962 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs3974590 - rs593713 | AA | MPPE1 | Chi square=4.475, P-value = 0.034, permutation P-value = 0.17 | Negative | |
| rs871044 - rs3974590 - rs593713 - rs602201 | GGAA | MPPE1 | Chi square=0.533, P-value = 0.465, permutation P-value = 0.991 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | AGAT | MPPE1 | Chi square=0.761, P-value = 0.383, permutation P-value = 0.966 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | AAGT | MPPE1 | Chi square=2.495, P-value = 0.114, permutation P-value = 0.503 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | GAGA | MPPE1 | Chi square=0.131, P-value = 0.717, permutation P-value = 1 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | AGAA | MPPE1 | Chi square=0.68, P-value = 0.41, permutation P-value = 0.977 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | AAGA | MPPE1 | Chi square=0.415, P-value = 0.52, permutation P-value = 0.997 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | GAAT | MPPE1 | Chi square=2.786, P-value = 0.095, permutation P-value = 0.431 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| rs871044 - rs3974590 - rs593713 - rs602201 | GAGT | MPPE1 | Chi square=0.651, P-value = 0.42, permutation P-value = 0.981 | Haplotype analysis of all four SNP configurations did not re...... Haplotype analysis of all four SNP configurations did not reveal an association with BPD. More... | Negative |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| MPPE1 | Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. | Positive |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
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Last update: March 31, 2016