Study Report
Basic Info
| Reference |
Altamura, A. C., 2010 PMID: 19923858
|
| Citation |
Altamura, A. C., E. Mundo, et al. (2010). "The MCP-1 gene (SCYA2) and mood disorders: preliminary results of a case-control association study." Neuroimmunomodulation 17(2): 126-131.
|
| Disease Type |
Bipolar Disorder & Major Depressive Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
36 BD type, 25 BD II, 35 MDD and 161 matched healthy controls. |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Italian |
| Gender |
34 men and 62 women for patients |
| Age Group |
adult
:
52.41(SD=12.88) years for patients
|
Detail Info
| Sample Diagnosis |
DSM-IV-TR criteria |
| Sample Status |
Exclusion criteria included other axis I disorders, as well as neurological illness, organic mental disorders and chronic immune or inflammatory disorders. |
| Technique |
PCR |
| Statistical Method |
Allelic and genotypic associations were done using X2 tests with respect to diagnostic subgroups. |
| Result Summary |
No genotypic or allelic association for the A-2518G polymorphism of SCYA2 was found considering cases and controls. Nevertheless, when comparisons were run between MDD versus BD patients (any subtype), a significantly higher frequency of the AA genotype and of the A allele was observed in subjects with BD. In addition, independently from diagnosis, a higher number of lifetime suicide attempts was found in subjects with the AA genotype of the A-2518G polymorphism of the MCP-1 gene. |
Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| SCYA2 A-2518G |
CCL2 |
point mutation |
A/G |
A |
Across all groups (controls, MDD, BD I, BD II): genotype: X2=8.215, d.f. = 6, P-value = 0.223; allele: X2 = 5.058, d.f. = 3, P-value = 0.168. Across patient groups (controls, cases): genotype: X2 = 8.140, d.f. = 4, P-value = 0.087; allele: X2 = 5.044, d.f. = 2, P-value = 0.080. MDD versus BD patients: genotype: X2 = 7.233, d.f. = 2, P-value = 0.027; allele: X2 = 4.730, d.f. = 1, P-value = 0.030.
|
No genotypic or allelic association for the A-2518G polymorp......
No genotypic or allelic association for the A-2518G polymorphism of SCYA2 was found considering cases and controls. Nevertheless, when comparisons were run between MDD versus BD patients (any subtype), a significantly higher frequency of the AA genotype and of the A allele was observed in subjects with BD. In addition, independently from diagnosis, a higher number of lifetime suicide attempts was found in subjects with the AA genotype of the A-2518G polymorphism of the MCP-1 gene.
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| CCL2 |
The present preliminary results, though limited by the relatively small sample, suggest a possible r......
The present preliminary results, though limited by the relatively small sample, suggest a possible role of the SCYA2 in conferring susceptibility to BD.
More...
|
Positive
|
Genetic factors reported by this study for SZ and/or MDD
