BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Winham S.J., 2014 PMID: 24882193
Citation	Winham, S. J., et al. (2014). "Bipolar disorder with comorbid binge eating history: A genome-wide association study implicates APOB." J Affect Disord 165: 151-158.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Genome-wide association study
Sample Size	1001 bipolar cases and 1034 controls
SNP/Region/Marker Size	729454 SNPs
Predominant Ethnicity	Caucasian
Population	European American
Age Group	adults

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Bipolar subjects were enrolled at multiple institutions over a period of 18 years. Subjects recruited at different times received different psychiatirc interviews based on the Diagnostic Interview for Genetic Studies 2, 3 or 4. All BD cases met the DSM-IV criteria for bipolar I disorder.
Replication Size	855 cases and 857 controls
Technique	genotyped on the Affymetrix Genome-Wide Human SNP Array 6.0
Statistical Method	All analyses were performed in PLINK version 1.07. Reported p-values are not corrected for multiple testing; statistical significance was determined based on a Bonferroni-corrected significance threshold of p<6.85E-8.
Result Summary	Top ranking SNPs in the discovery set included rs6006893 in PRR5, rs17045162 in ANK2, rs13233490 near PER4, rs4665788 and rs10198175 downstream of APOB, rs2367911 in CACNA2D1, and rs7249968 near ZNF536. Rs10198175 in APOB also demonstrated evidence of association in the replication sample and a meta-analysis of the two samples.

SNPs reported by this study for BD (count: 13)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6006893	ARHGAP8 PRR5-ARHGAP8 PRR5			Discovery set: OR=1.95, P-value=9.28E-06; Replication set: OR=1.20, P-value=0.491; Meta-analysis: OR=1.73, P-value=2.86E-05	Candidate SNPs identified from the discovery set. Candidate SNPs identified from the discovery set.	Trend
rs17045162	ANK2			Discovery set: OR=2.38, P-value=5.85E-05; Replication set: OR=0.66, P-value=0.422; Meta-analysis: OR=1.98, P-value=6.46E-04	No significant association was observed. No significant association was observed.	Negative
rs5019558	ANG RNASE4			Discovery set: OR=0.63, P-value=3.48E-05; Replication set: OR=1.01, P-value=0.943; Meta-analysis: OR=0.72, P-value=4.80E-04	No significant association was observed. No significant association was observed.	Negative
rs10491807	TAL2			BD+BE: OR=2.07, P-value=6.51E-06; BD-BE: OR=1.01, P-value=0.9070	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs10988393	C9orf50			BD+BE: OR=1.75, P-value=9.14E-06; BD-BE: OR=1.06, P-value=0.4825	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs17448220	LINC00939			BD+BE: OR=1.81, P-value=5.61E-06; BD-BE: OR=1.19, P-value=0.0578	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs10198175	APOB			BD+BE: OR=2.09, P-value=5.00E-06; BD-BE: OR=1.15, P-value=0.2441	In the analysis comparing the subtype of BD cases with BE to...... In the analysis comparing the subtype of BD cases with BE to healthy controls, little evidence of replication was observed besides rs10198175 in APOB. More...	Trend
rs7249968	ZNF536			BD+BE: OR=1.79, P-value=1.76E-06; BD-BE: OR=1.15, P-value=0.1109	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs2367911	CACNA2D1			BD+BE: OR=3.29, P-value=1.55E-06; BD-BE: OR=1.69, P-value=0.0096	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs17158578	PER4			BD+BE: OR=5.13, P-value=8.95E-07; BD-BE: OR=2.35, P-value=0.0041	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs10224816	NDUFA4			BD+BE: OR=2.16, P-value=5.78E-07; BD-BE: OR=1.18, P-value=0.1465	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs4665788	APOB			BD+BE: OR=1.79, P-value=4.01E-07; BD-BE: OR=1.16, P-value=0.0542	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
rs13233490	PER4			BD+BE: OR=6.37, P-value=3.87E-07; BD-BE: OR=2.61, P-value=0.0045	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend

Genes reported by this study for BD (count: 11)

Gene	Statistical Values/Author Comments	Result Category
ZNF536	rs7249968 near ZNF536 showed little evidence for association with BD. rs7249968 near ZNF536 showed little evidence for association with BD.	Trend
LINC00939	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
CACNA2D1	rs2367911 in CACNA2D1 showed little evidence for association with BD. rs2367911 in CACNA2D1 showed little evidence for association with BD.	Trend
ANK2	No significant association of SNP in this gene with BD was observed. No significant association of SNP in this gene with BD was observed.	Negative
RNASE4	No significant association of SNP in this gene with BD was observed. No significant association of SNP in this gene with BD was observed.	Negative
PRR5	rs6006893 in PRR5 showed little evidence for association with BD. rs6006893 in PRR5 showed little evidence for association with BD.	Trend
APOB	In the stratified analysis comparing the subtype of BD cases with BE to healthy controls, we identif...... In the stratified analysis comparing the subtype of BD cases with BE to healthy controls, we identified biologically plausible genetic associations with SNPs in APOB. More...	Trend
C9orf50	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
NDUFA4	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend
PER4	rs13233490 near PER4 showed little evidence for association with BD. rs13233490 near PER4 showed little evidence for association with BD.	Trend
TAL2	It showed little evidence for association with BD. It showed little evidence for association with BD.	Trend